ArticleClinical proteomics2010
Characterization of the Human Cervical Mucous Proteome.
Article in Clinical proteomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Different Forms of TFF3 in the Human Endocervix, including a Complex with IgG Fc Binding Protein (FCGBP), and Further Aspects of the Cervico-Vaginal Innate Immune Barrier.International journal of molecular sciences · 2024Article
- Light Microscopy and Proteomic Patterns of Ovulation in Cervical Mucus.Life (Basel, Switzerland) · 2022Article
- Mucus secretions from a conditionally reprogrammed primary endocervical cell culture.F&S science · 2022Article
- Review
- Detection of Ovarian Cancer Using Samples Sourced from the Vaginal Microenvironment.Journal of proteome research · 2020Article
- Protein Phosphorylation in Serine Residues Correlates with Progression from Precancerous Lesions to Cervical Cancer in Mexican Patients.BioMed research international · 2020Article
- Stress-Induced Mucus Secretion and Its Composition by a Combination of Proteomics and Metabolomics of the JellyfishMarine drugs · 2018Article
- Candidate biomarkers in the cervical vaginal fluid for the (self-)diagnosis of cervical precancer.Archives of gynecology and obstetrics · 2018Review
- A feasibility study to identify proteins in the residual Pap test fluid of women with normal cytology by mass spectrometry-based proteomics.Clinical proteomics · 2014Article
- Proteomic profiling of the planarian Schmidtea mediterranea and its mucous reveals similarities with human secretions and those predicted for parasitic flatworms.Molecular & cellular proteomics : MCP · 2012Article
- Sensitive and specific peak detection for SELDI-TOF mass spectrometry using a wavelet/neural-network based approach.PloS one · 2012Article
- The Cytotoxicity Mechanism of 6-Shogaol-Treated HeLa Human Cervical Cancer Cells Revealed by Label-Free Shotgun Proteomics and Bioinformatics Analysis.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Human papillomavirus and cervical cancer: biomarkers for improved prevention efforts.Future microbiology · 2011Review
- Discrimination of grade 2 and 3 cervical intraepithelial neoplasia by means of analysis of water soluble proteins recovered from cervical biopsies.Proteome science · 2011Article
- Use of cervicovaginal fluid for the identification of biomarkers for pathologies of the female genital tract.Proteome science · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionCervical cancer is among the most common cancers in women worldwide. Discovery of biomarkers for the early detection of cervical cancer would improve current screening practices and reduce the burden of disease.
objectiveIn this study, we report characterization of the human cervical mucous proteome as the first step towards protein biomarker discovery.
methodsThe protein composition was characterized using one- and two-dimensional gel electrophoresis, and liquid chromatography coupled with mass spectrometry. We chose to use this combination of traditional biochemical techniques and proteomics to allow a more comprehensive analysis. RESULTS AND
conclusionA total of 107 unique proteins were identified, with plasma proteins being most abundant. These proteins represented the major functional categories of metabolism, immune response, and cellular transport. Removal of high molecular weight abundant proteins by immunoaffinity purification did not significantly increase the number of protein spots resolved. We also analyzed phosphorylated and glycosylated proteins by fluorescent post-staining procedures. The profiling of cervical mucous proteins and their post-translational modifications can be used to further our understanding of the cervical mucous proteome.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.