ArticleThe EMBO journal2010
CaMKIIalpha interacts with M4 muscarinic receptors to control receptor and psychomotor function.
Article in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Physiological roles of CNS muscarinic receptors gained from knockout mice.Neuropharmacology · 2018Review
- Article
- Synaptic ERK2 Phosphorylates and Regulates Metabotropic Glutamate Receptor 1 In Vitro and in Neurons.Molecular neurobiology · 2017Article
- Ca(2+)/calmodulin-dependent protein kinase II interacts with group I metabotropic glutamate and facilitates receptor endocytosis and ERK1/2 signaling: role of β-amyloid.Molecular brain · 2015Article
- Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice.European journal of pharmacology · 2014Article
- CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- δ-opioid and dopaminergic processes in accumbens shell modulate the cholinergic control of predictive learning and choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Differential regulation of CaMKIIα interactions with mGluR5 and NMDA receptors by Ca(2+) in neurons.Journal of neurochemistry · 2013Article
- Dynamic downregulation of Nogo receptor expression in the rat forebrain by amphetamine.Neurochemistry international · 2013Article
- Phosphorylation and feedback regulation of metabotropic glutamate receptor 1 by calcium/calmodulin-dependent protein kinase II.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Upregulation of Npas4 protein expression by chronic administration of amphetamine in rat nucleus accumbens in vivo.Neuroscience letters · 2012Article
- Studying signal transduction in single dendritic spines.Cold Spring Harbor perspectives in biology · 2012Review
- Interactions and phosphorylation of postsynaptic density 93 (PSD-93) by extracellular signal-regulated kinase (ERK).Brain research · 2012Article
- Elimination of the vesicular acetylcholine transporter in the striatum reveals regulation of behaviour by cholinergic-glutamatergic co-transmission.PLoS biology · 2011Article
- Modulation of M4 muscarinic acetylcholine receptors by interacting proteins.Neuroscience bulletin · 2010Review
- CaMKIIα, a modulator of M4 muscarinic acetylcholine receptors.Communicative & integrative biology · 2010Article
- CaMKII hunkers down on the muscarinic M4 receptor to help curb cocaine-induced hyperlocomotion.The EMBO journal · 2010Article
- Article
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7 authors at 4 institutions in 2 countries.
Funding
Abstract
Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the mammalian brain and are essential for neuronal functions. These receptors are believed to be actively regulated by intracellular signals, although the underlying mechanisms are largely unknown. In this study, we show that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) binds directly and selectively to one of five mAChR subtypes, M4 receptors (M4Rs), at their C-terminal regions of second intracellular loops. This binding relies on Ca(2+) activation of the kinase and leads to the phosphorylation of M4Rs at a specific threonine site (Thr145). Complementary in vivo studies in rat striatal neurons enriched with M4Rs confirm that rising Ca(2+) recruits CaMKIIalpha to M4Rs to potentiate receptor signalling, which controls behavioural sensitivity to dopamine stimulation in an activity-dependent manner. Our data identify a new model of protein-protein interactions. In a Ca(2+)-sensitive manner, CaMKIIalpha regulates M4R efficacy and controls the acetylcholine-dopamine balance in the basal ganglia and also the dynamics of movement.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.