Reaching the limits of genome-wide significance in Alzheimer disease: back to the environment.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it.

1. Association between rs10046, rs1143704, rs767199, rs727479, rs1065778, rs1062033, rs1008805, and rs700519 polymorphisms in aromatase (CYP19A1) gene and Alzheimer's disease risk: a systematic review and meta-analysis involving 11,051 subjects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
   Pooled it
2. Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis.Human genetics · 2019
   Pooled it
3. Association between CLU gene rs11136000 polymorphism and Alzheimer's disease: an updated meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018
   Pooled it
4. Angiotensin-converting enzyme gene polymorphisms and risk for sporadic Alzheimer's disease: a meta-analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2015
   Pooled it
5. The CLU gene rs11136000 variant is significantly associated with Alzheimer's disease in Caucasian and Asian populations.Neuromolecular medicine · 2014
   Pooled it
6. Association between EXOC3L2 rs597668 polymorphism and Alzheimer's disease.CNS neuroscience & therapeutics · 2013
   Pooled it
7. Effects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer's Disease Risk.Environmental health perspectives · 2022
   Article
8. Rationale and methods for a multicenter clinical trial assessing exercise and intensive vascular risk reduction in preventing dementia (rrAD Study).Contemporary clinical trials · 2019
   Article
9. Relationship Between Alzheimer's Disease and the Immune System: A Meta-Analysis of Differentially Expressed Genes.Frontiers in neuroscience · 2018
   Article
10. Is aluminum exposure a risk factor for neurological disorders?Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018
    Review
11. Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms.Physiological reviews · 2017
    Review
12. Outdoor Ambient Air Pollution and Neurodegenerative Diseases: the Neuroinflammation Hypothesis.Current environmental health reports · 2017
    Review
13. Alzheimer's Disease Variants with the Genome-Wide Significance are Significantly Enriched in Immune Pathways and Active in Immune Cells.Molecular neurobiology · 2017
    Article
14. Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network.Molecular neurobiology · 2015
    Article
15. Integrating Genome-Wide Association Study and Brain Expression Data Highlights Cell Adhesion Molecules and Purine Metabolism in Alzheimer's Disease.Molecular neurobiology · 2015
    Article
16. Geographical variation in dementia: examining the role of environmental factors in Sweden and Scotland.Epidemiology (Cambridge, Mass.) · 2015
    Article
17. The earlier the better: Alzheimer's prevention, early detection, and the quest for pharmacological interventions.Culture, medicine and psychiatry · 2014
    Article
18. Elevated serum pesticide levels and risk for Alzheimer disease.JAMA neurology · 2014
    Article
19. Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
20. Copper phenotype in Alzheimer's disease: dissecting the pathway.American journal of neurodegenerative disease · 2013
    Article

Corrections and comments

• Comment on
  Genome-wide analysis of genetic loci associated with Alzheimer disease.2010

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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