High-dose vitamin D supplementation: too much of a good thing?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it.

1. Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis.Biomolecules & biomedicine · 2024
   Pooled it
2. Effects of intermittent or single high-dose vitamin D supplementation on risk of falls and fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
   Pooled it
3. Clinical review: Effect of vitamin D3 supplementation on improving glucose homeostasis and preventing diabetes: a systematic review and meta-analysis.The Journal of clinical endocrinology and metabolism · 2014
   Pooled it
4. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men.The Cochrane database of systematic reviews · 2014
   Pooled it
5. Vitamin D and type 2 diabetes: a systematic review.European journal of clinical nutrition · 2011
   Pooled it
6. Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function.Nutrients · 2024
   Trial
7. The Effect of Bolus Vitamin DJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
   Trial
8. Delivery of a Vitamin D Intervention in Homebound Older Adults Using a Meals-on-Wheels Program: A Pilot Study.Journal of the American Geriatrics Society · 2015
   Trial
9. Fortification of Yogurts with Vitamin D and Calcium Enhances the Inhibition of Serum Parathyroid Hormone and Bone Resorption Markers: A Double Blind Randomized Controlled Trial in Women over 60 Living in a Community Dwelling Home.The journal of nutrition, health & aging · 2015
   Trial
10. Hypovitaminosis D: which oral supplement therapy?The journal of nutrition, health & aging · 2014
    Trial
11. A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Trial
12. Serum 25-hydroxyvitamin D response to vitamin D3 supplementation 50,000 IU monthly in youth with HIV-1 infection.The Journal of clinical endocrinology and metabolism · 2012
    Trial
13. Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial.The American journal of clinical nutrition · 2011
    Trial
14. Vitamin D deficiency and disease conditions relevant to: Orthopaedic translation.Journal of orthopaedic translation · 2026
    Review
15. Optimizing serum 25(OH)D levels to mitigate the risk of age-related ocular diseases: insights from a large-scale prospective cohort study.Nutrition journal · 2025
    Article
16. Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows.Endocrine reviews · 2024
    Article
17. Very Low and High Levels of Vitamin D Are Associated with Shorter Leukocyte Telomere Length in 148,321 UK Biobank Participants.Nutrients · 2023
    Article
18. Nutraceuticals and Diet Supplements in Crohn's Disease: A General Overview of the Most Promising Approaches in the Clinic.Foods (Basel, Switzerland) · 2022
    Review
19. Vitamin D: Bolus Is Bogus-A Narrative Review.JBMR plus · 2021
    Article
20. Oral Administration of Quercetin or Its Derivatives Inhibit Bone Loss in Animal Model of Osteoporosis.Oxidative medicine and cellular longevity · 2020
    Review

Corrections and comments

• Commented on by
  High-dose oral vitamin D supplementation and risk of falls in older women.2010
• Commented on by
  High-dose oral vitamin D supplementation and risk of falls in older women.2010
• Comment on
  Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial.2010

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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