ReviewChemical senses2010
Achieving singularity in mammalian odorant receptor gene choice.
Review in Chemical senses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- The UHRF1 protein is a key regulator of retrotransposable elements and innate immune response to viral RNA in human cells.Epigenetics · 2023Article
- Article
- Spatial Determination of Neuronal Diversification in the Olfactory Epithelium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression.Epigenetics & chromatin · 2018Article
- Frequent and biased odorant receptor (OR) re-selection in an olfactory placode-derived cell line.PloS one · 2018Article
- Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated.eLife · 2017Article
- Regulatory role of G9a and LSD1 in the Transcription of Olfactory Receptors during Leukaemia Cell Differentiation.Scientific reports · 2017Article
- Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq.Scientific reports · 2015Article
- Identification of novel post-transcriptional features in olfactory receptor family mRNAs.Nucleic acids research · 2015Article
- Differentiation of developing olfactory neurons analysed in terms of coupled epigenetic landscapes.Nucleic acids research · 2013Article
- Divergence of mammalian higher order chromatin structure is associated with developmental loci.PLoS computational biology · 2013Article
- Global expression profiling of globose basal cells and neurogenic progression within the olfactory epithelium.The Journal of comparative neurology · 2013Article
- Establishing and maintaining gene expression patterns: insights from sensory receptor patterning.Development (Cambridge, England) · 2013Review
- Environmentally induced transgenerational epigenetic reprogramming of primordial germ cells and the subsequent germ line.PloS one · 2013Article
- Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in Plasmodium falciparum.Cellular microbiology · 2012Article
- Epigenetic regulation of olfactory receptor gene expression by the Myb-MuvB/dREAM complex.Genes & development · 2012Article
- Genomics of mature and immature olfactory sensory neurons.The Journal of comparative neurology · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Odor discrimination requires differential expression of odor detectors. In fact, olfactory input to the brain is organized in units (glomeruli) innervated only by olfactory sensory neurons that express the same odorant receptor (OR). Therefore, discriminatory capacity is maximized if each sensory neuron expresses only one allele of a single OR gene, a postulate sometimes canonized as the "one neuron-one receptor rule." OR gene choice appears to result from a hierarchy of processes: differential availability of the alleles of each OR gene, zonal exclusion (or selection), OR gene switching during the initiation of OR gene transcription, and OR-dependent feedback to solidify the choice of one OR gene. The mechanisms underlying these processes are poorly understood, though a few elements are known or suspected. For example, the mechanism of activation of OR gene transcription appears to work in part through a few homeobox transcription factors (Emx2, and perhaps Lhx2) and the Ebf family of transcription factors. Further insights will probably come from several directions, but a promising hypothesis is that epigenetic mechanisms contribute to all levels of the hierarchical control of OR gene expression, especially the repressive events that seem to be necessary to achieve the singularity of OR gene choice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.