Evidence map›Paper›PMID 20460184›Full record

ReviewInternational review of cell and molecular biology2010

New insights into the regulation of the actin cytoskeleton by tropomyosin.

C-L Albert Wang, Lynne M Coluccio

Open access · greenAbstract readReview
In one paragraph

Review in International review of cell and molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
54.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Review
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  7. Review
  8. Review
  9. Introducing a new anti-Veterinary research forum : an international quarterly journal · 2021
    Article
  10. Epigenetics in psoriasis: perspective of DNA methylation.Molecular genetics and genomics : MGG · 2021
    Review
  11. Review
  12. Actin-tropomyosin distribution in non-muscle cells.Journal of muscle research and cell motility · 2020
    Review
  13. Review
  14. Article
  15. Article
  16. Cytoskeletal Tropomyosin as a Biomarker inJournal of clinical medicine research · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

C-L Albert WangBoston Biomedical Research Institute, Watertown, MA, USA.
Lynne M Coluccio
Boston Biomedical Research Institute · US

Funding

Role of myosin 1c in adaptation in the inner earR01DC008793 · NIDCD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COLUCCIO, LYNNE M · 2008 to 2012
$3.9M
Regulation of Vascular Smooth Muscle CytoskeletonR01HL092252 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WANG, CHIH-LUEH ALBERT · 2009 to 2012
$3.0M
Role of myosin 1c in adaptation in the inner earR55DC008793 · NIDCD · BOSTON BIOMEDICAL RESEARCH INSTITUTE · PI COLUCCIO, LYNNE M · 2007 to 2007
$100k
NHLBI NIH HHS HL092252NHLBI NIH HHS R01 HL092252NIDCD NIH HHS DC08793NIDCD NIH HHS R01 DC008793NIDCD NIH HHS R55 DC008793
6 · The paper itself

Abstract

The actin cytoskeleton is regulated by a variety of actin-binding proteins including those constituting the tropomyosin family. Tropomyosins are coiled-coil dimers that bind along the length of actin filaments. In muscles, tropomyosin regulates the interaction of actin-containing thin filaments with myosin-containing thick filaments to allow contraction. In nonmuscle cells where multiple tropomyosin isoforms are expressed, tropomyosins participate in a number of cellular events involving the cytoskeleton. This chapter reviews the current state of the literature regarding tropomyosin structure and function and discusses the evidence that tropomyosins play a role in regulating actin assembly.

Indexed as

ActinsAmino Acid SequenceAnimalsCalmodulin-Binding ProteinsCell MembraneCytoskeletonHumansMolecular Motor ProteinsMolecular Sequence DataMuscle ContractionMyosinsNeoplasm MetastasisPhosphorylationProtein IsoformsTropomyosinActinsCalmodulin-Binding ProteinsMolecular Motor ProteinsMyosinsProtein IsoformsTropomyosin

Identifiers

PMID20460184
PMCPMC2923581
OpenAlexW1708389525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.