ArticleInternational journal for parasitology2010
Low infectivity of Plasmodium falciparum gametocytes to Anopheles gambiae following treatment with sulfadoxine-pyrimethamine in Mali.
Article in International journal for parasitology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Protocols for Plasmodium gametocyte production in vitro: an integrative review and analysis.Parasites & vectors · 2022Pooled it
- Pooled it
- Trial
- Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness.Malaria journal · 2021Trial
- Trial
- Trial
- Prevalence ofPathogens (Basel, Switzerland) · 2026Article
- A NovelAntimicrobial agents and chemotherapy · 2022Article
- HIV-1 Impact on Malaria Transmission: A Complex and Relevant Global Health Concern.Frontiers in cellular and infection microbiology · 2021Review
- Plasmodium Gametocytes in Field Studies: Do We Measure Commitment to Transmission or Detectability?Trends in parasitology · 2018Review
- Differential infectivity of gametocytes after artemisinin-based combination therapy of uncomplicated falciparum malaria.African journal of laboratory medicine · 2018Article
- Assessing Gametocyte Carriage in Treated Asymptomatic Falciparum Carriers in Africa.EBioMedicine · 2016Article
- How important is gametocyte clearance after malaria therapy?BMC medicine · 2016Article
- Gametocyte Clearance Kinetics Determined by Quantitative Magnetic Fractionation in Melanesian Children with Uncomplicated Malaria Treated with Artemisinin Combination Therapy.Antimicrobial agents and chemotherapy · 2015Article
- Article
- Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.Malaria journal · 2014Review
- Strategic use of antimalarial drugs that block falciparum malaria parasite transmission to mosquitoes to achieve local malaria elimination.Parasitology research · 2014Review
- Modeling within-host effects of drugs on Plasmodium falciparum transmission and prospects for malaria elimination.PLoS computational biology · 2014Article
- HIV treatments have malaria gametocyte killing and transmission blocking activity.The Journal of infectious diseases · 2013Article
- Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination.Clinical microbiology reviews · 2011Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
Abstract
Sulfadoxine-pyrimethamine (SP) treatment increases the rate of gametocyte carriage and selects SP resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS), raising concerns of increased malaria transmission and spread of drug resistance. In a setting in Mali where SP was highly efficacious, we measured the prevalence of DHFR and DHPS mutations in P. falciparum infections with microscopy-detected gametocytes following SP treatment, and used direct feeding to assess infectivity to Anopheles gambiae sensu lato. Children and young adults presenting with uncomplicated malaria were treated with SP or chloroquine and followed for 28 days. Gametocyte carriage peaked at 67% 1 week after treatment with a single dose of SP. Those post-SP gametocytes carried significantly more DHFR and DHPS mutations than pre-treatment asexual parasites from the same population. Only 0.5% of 1728 mosquitoes fed on SP-treated gametocyte carriers developed oocysts, while 11% of 198 mosquitoes fed on chloroquine-treated gametocyte carriers were positive for oocysts. This study shows that in an area of high SP efficacy, although SP treatment sharply increased gametocyte carriage, the infectiousness of these gametocytes to the vector may be very low. Accurate and robust methods for measuring infectivity are needed to guide malaria control interventions that affect transmission.
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