ArticleReproductive biology and endocrinology : RB&E2010
A comparative genome analysis of gene expression reveals different regulatory mechanisms between mouse and human embryo pre-implantation development.
Article in Reproductive biology and endocrinology : RB&E, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Glutamate can act as a signaling molecule in mouse preimplantation embryos†.Biology of reproduction · 2022Article
- Transcriptional profiles of crossbred embryos derived from yak oocytes in vitro fertilized with cattle sperm.Scientific reports · 2018Article
- From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies.Healthcare (Basel, Switzerland) · 2016Article
- Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.Nature biotechnology · 2015Article
- Identification of 4438 novel lincRNAs involved in mouse pre-implantation embryonic development.Molecular genetics and genomics : MGG · 2015Article
- Gene expression profiling in human lung development: an abundant resource for lung adenocarcinoma prognosis.PloS one · 2014Article
- Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.PloS one · 2014Article
- ART and health: clinical outcomes and insights on molecular mechanisms from rodent studies.Molecular human reproduction · 2013Review
- Preimplantation stress and development.Birth defects research. Part C, Embryo today : reviews · 2012Review
- RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells.Molecular and cellular biology · 2012Article
- What Are the bona fide GSK3 Substrates?International journal of Alzheimer's disease · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPre-implantation development is a crucial step in successful implantation and pregnancy in mammals. It has been studied in depth, but mostly in laboratory animal models. Less is known about the regulatory mechanism involved in the pre-implantation development in humans and about the comparative aspects.
methodsHere, we employed the microarray datasets from the public database library of GEO and applied comparative analysis of genome wide temporal gene expression data based on statistical analysis and functional annotation for both mouse and human, demonstrating the discordance between the regulatory mechanisms of both mouse and human pre-implantation development.
resultsThere were differences between mouse and human pre-implantation development both in the global gene expression pattern and in the expression changes of individual genes at each stage, including different major transient waves of transcription profiles and some stage-specific genes and significantly related pathways. There also appeared to be different functional changes from one stage to another between mouse and human.
conclusionsThe analysis presented here lead to interesting and complementary conclusions that the regulatory mechanism of human pre-implantation development is not completely the same as the mouse. Not as the fact that 1-cell to 2-cell stage is important for mouse pre-implantation development, the 4-cell stage and 8-cell stage are both essential for human. Unlike in mouse, of which most of pathways found were related to energy, RNA and protein metabolism, the identified pathways in human were mostly disease-related and associated with human pre-implantation embryonic development. All of these suggest that a further comparative analysis should be required for applying the result of mouse expression data to human research or therapy, particularly in pre-implantation developments. Our study provides several potential targets of genes and pathways for studying the regulatory mechanism of human pre-implantation development using mouse model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.