ArticleBMC genetics2010
Evaluating the transferability of Hapmap SNPs to a Singapore Chinese population.
Article in BMC genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Pooled it
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- Sensitization to Dog Dander Allergen Can f 1 is Associated with Asthma Symptom Severity and Exacerbations in a Singapore-Malaysia Cohort.Journal of asthma and allergy · 2026Article
- <italic>TXK</italic> Functional Variants Contribute to Asthma by Regulating Th1 and Th17 Cytokine Pathways.International archives of allergy and immunology · 2025Article
- Functional Polymorphisms Regulate FOXO1 Transcript Expression and Contribute to the Risk and Symptom Severity of HDM-Induced Allergic Rhinitis.International archives of allergy and immunology · 2025Article
- Sensitization to oil palm pollen associates with risks and severity of allergic diseases.The World Allergy Organization journal · 2024Article
- Sensitization to Airborne Fungal Allergens Associates with Asthma and Allergic Rhinitis Presentation and Severity in the Singaporean/Malaysian Population.Mycopathologia · 2021Article
- The Asthma-associated PER1-like domain-containing protein 1 (PERLD1) Haplotype Influences Soluble Glycosylphosphatidylinositol Anchor Protein (sGPI-AP) Levels in Serum and Immune Cell Proliferation.Scientific reports · 2020Article
- Article
- Poor reproducibility of allergic rhinitis SNP associations.PloS one · 2013Article
- Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study.BMC medical genetics · 2012Article
- Genome-wide association study identifies PERLD1 as asthma candidate gene.BMC medical genetics · 2011Article
- Genetic predisposition for atopy and allergic rhinitis in the Singapore Chinese population.Asia Pacific allergy · 2011Article
- Pharmacogenomic technologies: a necessary "luxury" for better global public health?Globalization and health · 2011Article
- Variation in Uteroglobin-Related Protein 1 (UGRP1) gene is associated with allergic rhinitis in Singapore Chinese.BMC medical genetics · 2011Article
- Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe International Hapmap project serves as a valuable resource for human genome variation data, however its applicability to other populations has yet to be exhaustively investigated. In this paper, we use high density genotyping chips and resequencing strategies to compare the Singapore Chinese population with the Hapmap populations. First we compared 1028 and 114 unrelated Singapore Chinese samples genotyped using the Illumina Human Hapmap 550 k chip and Affymetrix 500 k array respectively against the 270 samples from Hapmap. Secondly, data from 20 candidate genes on 5q31-33 resequenced for an asthma candidate gene based study was also used for the analysis.
resultsA total of 237 SNPs were identified through resequencing of which only 95 SNPs (40%) were in Hapmap; however an additional 56 SNPs (24%) were not genotyped directly but had a proxy SNP in the Hapmap. At the genome-wide level, Singapore Chinese were highly correlated with Hapmap Han Chinese with correlation of 0.954 and 0.947 for the Illumina and Affymetrix platforms respectively with deviant SNPs randomly distributed within and across all chromosomes.
conclusionsThe high correlation between our population and Hapmap Han Chinese reaffirms the applicability of Hapmap based genome-wide chips for GWA studies. There is a clear population signature for the Singapore Chinese samples and they predominantly resemble the southern Han Chinese population; however when new migrants particularly those with northern Han Chinese background were included, population stratification issues may arise. Future studies needs to address population stratification within the sample collection while designing and interpreting GWAS in the Chinese population.
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