Evidence map›Paper›PMID 20458729›Full record

ReviewJournal of cellular physiology2010

Navigating the nucleotide excision repair threshold.

Liren Liu, Jennifer Lee, Pengbo Zhou

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of cellular physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
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  9. Review
  10. Circadian rhythm disruption in cancer biology.Molecular medicine (Cambridge, Mass.) · 2012
    Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Liren LiuDepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences, New York, New York 10065, USA.
Jennifer Lee
Pengbo Zhou
Cornell University · US

Funding

Regulation of Nucleotide Excision Repair by ProteolysisR01CA098210 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, PENGBO · 2003 to 2013
$3.3M
Regulation of Nucleotide Excision Repair by ProteolysisR56CA098210 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, PENGBO · 2008 to 2008
$329k
NCI NIH HHS CA098210NCI NIH HHS R01 CA098210NCI NIH HHS R56 CA098210
6 · The paper itself

Abstract

Nucleotide excision repair (NER) is the primary DNA repair pathway that removes helix-distorting DNA strand damage induced by ultraviolet light irradiation or chemical carcinogens to ensure genome integrity. While the core NER proteins that carry out damage recognition, excision, and repair reactions have been identified and extensively characterized, and the NER pathway has been reconstituted in vitro, the regulatory pathways that govern the threshold levels of NER have not been fully elucidated. This mini-review focuses on recently discovered transcriptional and post-translational mechanisms that specify the capacity of NER, and suggests the potential implications of modulating NER activity in cancer prevention and therapeutic intervention.

Indexed as

DNA DamageDNA RepairAnimalsBiological ClocksCircadian RhythmGene Expression RegulationHumansTranscription, GeneticXeroderma Pigmentosum Group A ProteinXeroderma Pigmentosum Group A Protein

Identifiers

PMID20458729
PMCPMC2897951
OpenAlexW2020911919

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.