ArticleEuropean journal of immunology2010
A novel immunoregulatory function for IL-23: Inhibition of IL-12-dependent IFN-γ production.
Article in European journal of immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- IL-23 and monocyte interactions redirect human Th17.1 cells to an IL-17AFrontiers in immunology · 2026Article
- Immunomodulation in dengue: towards deciphering dengue severity markers.Cell communication and signaling : CCS · 2024Review
- ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression.Molecular cancer research : MCR · 2021Article
- Implications of a 'Third Signal' in NK Cells.Cells · 2021Review
- STAT4: an immunoregulator contributing to diverse human diseases.International journal of biological sciences · 2020Review
- Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Regulation of IL-17A and implications for TGF-β1 comodulation of airway smooth muscle remodeling in severe asthma.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019Article
- Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis.Arthritis research & therapy · 2018Article
- Cell wall mannan of Candida krusei mediates dendritic cell apoptosis and orchestrates Th17 polarization via TLR-2/MyD88-dependent pathway.Scientific reports · 2018Article
- Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer.Cold Spring Harbor perspectives in biology · 2018Review
- IL-23R Deficiency Does Not Impact Atherosclerotic Plaque Development in Mice.Journal of the American Heart Association · 2018Article
- Adoptively transferred donor IL-17-producing CD4Cellular & molecular immunology · 2018Article
- Disease Tolerance and Pathogen Resistance Genes May UnderlieFrontiers in immunology · 2018Article
- Immunological mechanism of low-dose priming radiation resistance in walker-256 tumor model mice.Experimental and therapeutic medicine · 2017Article
- Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56Frontiers in immunology · 2017Article
- Article
- MicroRNA-155 regulates host immune response to postviral bacterial pneumonia via IL-23/IL-17 pathway.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Regulation of Natural Killer Cell Function by STAT3.Frontiers in immunology · 2016Review
- IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology.Nature communications · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Most studies investigating the function of IL-23 have concluded that it promotes IL-17-secreting T cells. Although some reports have also characterized IL-23 as having redundant pro-inflammatory effects with IL-12, we have instead found that IL-23 antagonizes IL-12-induced secretion of IFN-γ. When splenocytes or purified populations of T cells were cultured with IL-23, IFN-γ secretion in response to IL-12 was dramatically reduced. The impact of IL-23 was most prominent in CD8(+) T cells, but was also observed in NK and CD4(+) T cells. Mechanistically, the IL-23 receptor was not required for this phenomenon, and IL-23 inhibited signaling through the IL-12 receptor by reducing IL-12-induced signal transducer and activator of transcription 4 (STAT4) phosphorylation. IL-23 was also able to reduce IFN-γ secretion by antagonizing endogenously produced IL-12 from Listeria monocytogenes (LM)-infected macrophages. In vivo, LM infection induced higher serum IFN-γ levels and a greater percentage of IFN-γ(+)CD8(+) T cells in IL-23p19-deficient mice as compared with WT mice. This increase in IFN-γ production coincided with increased LM clearance at days 2 and 3 post-infection. Our data suggest that IL-23 may be a key factor in determining the responsiveness of lymphocytes to IL-12 and their subsequent secretion of IFN-γ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.