ArticleJournal of physics. Condensed matter : an Institute of Physics journal2010
Cell shape, spreading symmetry and the polarization of stress-fibers in cells.
Article in Journal of physics. Condensed matter : an Institute of Physics journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Persistence diagrams as morphological signatures of cells: A method to measure and compare cells within a population.PLoS computational biology · 2026Article
- TRPV4-Mediated Mechanosensing Regulates the Endothelial-to-Mesenchymal Transition: Implications for Atherosclerosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Melt-Extrusion Additive Manufacturing for Tissue Engineering: Applications and Limitations.3D printing and additive manufacturing · 2025Article
- Effects of Shear and Extensional Stresses on Cells: Investigation in a Spiral Microchannel and Contraction-Expansion Arrays.ACS biomaterials science & engineering · 2025Review
- Acute contact with profibrotic macrophages mechanically activates fibroblasts via αvβ3 integrin-mediated engagement of Piezo1.Science advances · 2024Article
- Myotube formation on micropatterns guiding by centripetal cellular motility and crowding.Materials today. Bio · 2024Article
- Metal-Induced Energy Transfer (MIET) for Live-Cell Imaging with Fluorescent Proteins.ACS nano · 2023Article
- Cytochalasin B Influences Cytoskeletal Organization and Osteogenic Potential of Human Wharton's Jelly Mesenchymal Stem Cells.Pharmaceuticals (Basel, Switzerland) · 2023Article
- FilamentSensor 2.0: An open-source modular toolbox for 2D/3D cytoskeletal filament tracking.PloS one · 2023Article
- Cytochalasin B Modulates Nanomechanical Patterning and Fate in Human Adipose-Derived Stem Cells.Cells · 2022Article
- On the Three-Dimensional Correlation Between Myofibroblast Shape and Contraction.Journal of biomechanical engineering · 2021Article
- Article
- Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks.PLoS genetics · 2020Article
- Physicochemically Tuned Myofibroblasts for Wound Healing Strategy.Scientific reports · 2019Article
- Morphometric analysis of spread platelets identifies integrin αScientific reports · 2018Article
- Dual-color metal-induced and Förster resonance energy transfer for cell nanoscopy.Molecular biology of the cell · 2018Article
- Actomyosin meshwork mechanosensing enables tissue shape to orient cell force.Nature communications · 2017Article
- Geometry and network connectivity govern the mechanics of stress fibers.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Effects of 3D geometries on cellular gradient sensing and polarization.Physical biology · 2016Article
- Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor.Nature materials · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The active regulation of cellular forces during cell adhesion plays an important role in the determination of cell size, shape and internal structure. While on flat, homogeneous and isotropic substrates some cells spread isotropically, others spread anisotropically and assume elongated structures. In addition, in their native environment as well as in vitro experiments, the cell shape and spreading asymmetry can be modulated by the local distribution of adhesive molecules and topography of the environment. We present a simple elastic model, and experiments on stem cells to explain the variation of cell size with the matrix rigidity. In addition, we predict the experimental consequences of two mechanisms of acto-myosin polarization and focus here on the effect of the cell spreading asymmetry on the regulation of the stress-fiber alignment in the cytoskeleton. We show that when cell spreading is sufficiently asymmetric the alignment of acto-myosin forces in the cell increases monotonically with the matrix rigidity; however, in general this alignment is non-monotonic as shown previously. These results highlight the importance of the symmetry characteristics of cell spreading in the regulation of cytoskeleton structure and suggest a mechanism by which different cell types may acquire different morphologies and internal structures in different mechanical environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.