ReviewNature reviews. Rheumatology2010
Microparticles as autoadjuvants in the pathogenesis of SLE.
Review in Nature reviews. Rheumatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Platelet-Derived Extracellular Vesicles in Arterial Thrombosis.Advances in experimental medicine and biology · 2023Article
- Microparticles in Autoimmunity: Cause or Consequence of Disease?Frontiers in immunology · 2022Review
- Induction of NF-κB inflammatory pathway in monocytes by microparticles from patients with systemic lupus erythematosus.Heliyon · 2020Article
- Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases.International journal of molecular sciences · 2019Review
- Characterization of cell-derived microparticles in synovial fluid and plasma of patients with rheumatoid arthritis.Rheumatology international · 2019Article
- Circulating DNA in rheumatoid arthritis: pathological changes and association with clinically used serological markers.Arthritis research & therapy · 2017Article
- The many ways tissue phagocytes respond to dying cells.Immunological reviews · 2017Review
- Parvovirus B19-induced vascular damage in the heart is associated with elevated circulating endothelial microparticles.PloS one · 2017Article
- The Role of Microparticles in Rheumatic Diseases and their Potentials as Therapeutic Tools.Journal of molecular immunology · 2016Article
- Microparticles That Form Immune Complexes as Modulatory Structures in Autoimmune Responses.Mediators of inflammation · 2015Review
- Review
- Microvesicles: potential markers and mediators of endothelial dysfunction.Current opinion in endocrinology, diabetes, and obesity · 2012Review
- Impaired clearance of apoptotic cells in germinal centers: implications for loss of B cell tolerance and induction of autoimmunity.Immunologic research · 2011Review
- Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis.Seminars in immunopathology · 2011Review
- Disturbances of apoptotic cell clearance in systemic lupus erythematosus.Arthritis research & therapy · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleic acids represent the main source of autoantigens in systemic lupus erythematosus (SLE). DNA and RNA can exit the cell during cell death and, in the extracellular space, can be immunostimulatory. Also extracellularly, DNA and RNA can be incorporated into microparticles (MPs)-small, membrane-bound vesicles released from dying cells by blebbing. We suggest that MPs display autoantigens, such as RNA and DNA, in a highly immunostimulatory manner, enabling them to function as autoadjuvants. In the bone marrow, nucleic-acid-containing MP autoadjuvants might induce B-cell tolerance, whereas in the periphery, they might stimulate mature B cells that have escaped central tolerance. Indeed, because MP autoadjuvants can trigger several receptors, they could effectively provide apoptotic or activating signals to B cells. We would therefore advance the idea that a model for SLE based on MP autoadjuvants can provide a new paradigm to elucidate the mechanisms by which DNA and RNA affect the immune system and critically influence B-cell fate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.