ReviewNature reviews. Urology2010
Immunologic mechanisms in RCC and allogeneic renal transplant rejection.
Review in Nature reviews. Urology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Exploring the mechanism of BK polyomavirus-associated nephropathy through consensus gene network approach.PloS one · 2023Article
- Skin cancer outcomes and risk factors in renal transplant recipients: Analysis of organ procurement and transplantation network data from 2000 to 2021.Frontiers in oncology · 2022Article
- Identifying tumor antigens and immune subtypes of renal cell carcinoma for immunotherapy development.Frontiers in immunology · 2022Article
- Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation.Journal of immunology research · 2020Article
- Red cell distribution width is associated with presence, stage, and grade in patients with renal cell carcinoma.Disease markers · 2014Article
- Dramatic early event in chronic allograft nephropathy: increased but not decreased expression of MMP-9 gene.Diagnostic pathology · 2013Article
- [Prostate carcinoma: vaccination as a new option for treatment].Der Urologe. Ausg. A · 2012Review
- [Renal cell carcinoma: recent developments in diagnostics and therapy].Der Urologe. Ausg. A · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tolerance state that exists between renal cell carcinoma (RCC) and the host's immune system would be an ideal situation in the setting of human kidney transplantation, in which graft tolerance is the ultimate goal of immunosuppressive therapy. On the other hand, acute rejection, as it appears in renal allografts, would be the optimal immunologic situation in patients with RCC. Analysis of the underlying mechanisms of acute allograft rejection and local pro-tumor immunosuppression could help to identify potential therapeutic targets for inducing immune tolerance in allograft recipients and immune rejection in RCC patients. Experimental kidney transplantation might be a suitable model in which to analyze these processes. Macrophages are a prominent and vital cell type in the cellular infiltrate seen in both RCC and renal allografts. Depending on their polarization, they can initiate and promote either proinflammatory or pro-tumor responses, which lead to tissue rejection or acceptance, respectively. Improved understanding of macrophage biology could lead to therapeutic modification of their function in order to promote a desirable immunologic response in either RCC or transplant tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.