Evidence map›Paper›PMID 20458159›Full record

ArticleJournal of veterinary science2010

Production of specific antibodies against SARS-coronavirus nucleocapsid protein without cross reactivity with human coronaviruses 229E and OC43.

Hyun Kyoung Lee, Byoung Hee Lee, Seung Hyeok Seok, Min Won Baek, Hui Young Lee, Dong Jae Kim, Yi Rang Na, Kyoung Jin Noh, Sung Hoon Park, Dutta Noton Kumar and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 107 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Hyun Kyoung LeeDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
Byoung Hee Lee
Seung Hyeok Seok
Min Won Baek
Hui Young Lee
Dong Jae Kim
Yi Rang Na
Kyoung Jin Noh
Sung Hoon Park
Dutta Noton Kumar
Hiroaki Kariwa
Mina Nakauchi
Suk Jin Heo
Jae Hak Park
Seoul National University · KRHokkaido University · JPCenter for Biologics Evaluation and Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome (SARS) is a life-threatening disease for which accurate diagnosis is essential. Although many tools have been developed for the diagnosis of SARS, false-positive reactions in negative sera may occur because of cross-reactivity with other coronaviruses. We have raised polyclonal and monoclonal antibodies (Abs) using a recombinant form of the SARS virus nucleocapsid protein. Cross-reactivity of these anti-SARS Abs against human coronavirus (HCoV) 229E and HCoV OC43 were determined by Western blotting. The Abs produced reacted with recombinant SARS virus nucleocapsid protein, but not with HCoV 229E or HCoV OC43.

Indexed as

Antibodies, ViralBlotting, WesternCoronavirus 229E, HumanCoronavirus OC43, HumanCross ReactionsHumansNucleocapsid ProteinsRecombinant ProteinsSevere Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusAntibodies, ViralNucleocapsid ProteinsRecombinant Proteins

Identifiers

PMID20458159
PMCPMC2873818
OpenAlexW2130344921

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.