ArticleGenome research2010
Evolution of a genomic regulatory domain: the role of gene co-option and gene duplication in the Enhancer of split complex.
Article in Genome research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Conserved cellular signals and mechanisms accompany the reproductive shutdown of honey bee (Apis mellifera) queens for dispersal.Communications biology · 2026Article
- Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.International journal of molecular sciences · 2023Review
- Evolution and genomic organization of the insect sHSP gene cluster and coordinate regulation in phenotypic plasticity.BMC ecology and evolution · 2021Article
- Genome Architecture Facilitates Phenotypic Plasticity in the Honeybee (Apis mellifera).Molecular biology and evolution · 2020Article
- Analysis of the genome of the New Zealand giant collembolan (Holacanthella duospinosa) sheds light on hexapod evolution.BMC genomics · 2017Article
- Notch signalling mediates reproductive constraint in the adult worker honeybee.Nature communications · 2016Article
- Origin and evolution of the enhancer of split complex.BMC genomics · 2015Article
- Multispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Family.Molecular biology and evolution · 2015Article
- The genomes of two key bumblebee species with primitive eusocial organization.Genome biology · 2015Article
- Evidence for the plasticity of arthropod signal transduction pathways.Development genes and evolution · 2014Article
- Article
- The Drosophila enhancer of split gene complex: architecture and coordinate regulation by notch, cohesin, and polycomb group proteins.G3 (Bethesda, Md.) · 2013Article
- Classification and evolutionary analysis of the basic helix-loop-helix gene family in the green anole lizard, Anolis carolinensis.Molecular genetics and genomics : MGG · 2013Article
- Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repression.Molecular and cellular biology · 2012Article
- Ancestral and conserved cis-regulatory architectures in developmental control genes.Developmental biology · 2012Article
- The molecular clockwork of the fire ant Solenopsis invicta.PloS one · 2012Article
- Comparative and evolutionary analysis of the HES/HEY gene family reveal exon/intron loss and teleost specific duplication events.PloS one · 2012Article
- The Enhancer of split complex arose prior to the diversification of schizophoran flies and is strongly conserved between Drosophila and stalk-eyed flies (Diopsidae).BMC evolutionary biology · 2011Article
- Notch signaling does not regulate segmentation in the honeybee, Apis mellifera.Development genes and evolution · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila Enhancer of split complex [E(spl)-C] is a remarkable complex of genes many of which are effectors or modulators of Notch signaling. The complex contains different classes of genes including four bearded genes and seven basic helix-loop-helix (bHLH) genes. We examined the evolution of this unusual complex by identifying bearded and bHLH genes in the genome sequences of Arthropods. We find that a four-gene E(spl)-C, containing three bHLH genes and one bearded gene, is an ancient component of the genomes of Crustacea and Insects. The complex is well conserved in insects but is highly modified in Drosophila, where two of the ancestral genes of the complex are missing, and the remaining two have been duplicated multiple times. Through examining the expression of E(spl)-C genes in honeybees, aphids, and Drosophila, we determined that the complex ancestrally had a role in Notch signaling. The expression patterns of genes found inserted into the complex in some insects, or that of ancestral E(spl)-C genes that have moved out of the complex, imply that the E(spl)-C is a genomic domain regulated as a whole by Notch signaling. We hypothesize that the E(spl)-C is a Notch-regulated genomic domain conserved in Arthropod genomes for around 420 million years. We discuss the consequence of this conserved domain for the recruitment of novel genes into the Notch signaling cascade.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.