ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2010
Pregnancy outcome after treatment for Wilms tumor: a report from the national Wilms tumor long-term follow-up study.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Low-dose ionizing radiation and adverse birth outcomes: a systematic review and meta-analysis.International archives of occupational and environmental health · 2023Pooled it
- Outcome of patients with Stage II/favorable histology Wilms tumor with and without local tumor spill: a report from the National Wilms Tumor Study Group.Pediatric blood & cancer · 2014Trial
- Overview and future studies of potential hereditary effects of parental exposure to atomic bomb radiation on their offspring.Carcinogenesis · 2025Review
- Beating the Odds: A Successful Pregnancy in a Patient With ALK-Rearranged Lung Cancer on Alectinib.Case reports in medicine · 2025Article
- Risks of long-term mortality and chronic health conditions experienced by Wilms tumor survivors.Translational pediatrics · 2023Article
- Article
- White paper: Oncofertility in pediatric patients with Wilms tumor.International journal of cancer · 2022Article
- Enhancing Evidence for Preconception and Prenatal Counseling on Obstetrical Risks After Cancer.Journal of the National Cancer Institute · 2022Article
- Systematic review of the immunological landscape of Wilms tumors.Molecular therapy oncolytics · 2021Review
- Pregnancy, time to pregnancy and obstetric outcomes among female childhood cancer survivors: results of the DCOG LATER-VEVO study.Journal of cancer research and clinical oncology · 2020Article
- Looking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments.Journal of assisted reproduction and genetics · 2020Review
- Factors responsible for stage III disease in patients with Wilms tumor enrolled in the JWiTS-2 study.Pediatric surgery international · 2019Article
- Update on Wilms tumor.Journal of pediatric surgery · 2019Review
- Radiations and female fertility.Reproductive biology and endocrinology : RB&E · 2018Review
- Feasibility and accuracy of UF/NCI phantoms and Monte Carlo retrospective dosimetry in children treated on National Wilms Tumor Study protocols.Pediatric blood & cancer · 2018Article
- Fertility and pregnancy in cancer survivors.Obstetric medicine · 2018Review
- Reproductive Function and Outcomes in Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Review.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Review
- Pregnancy Achieved Using Donor Eggs in Cancer Survivors with Treatment-Induced Ovarian Failure: Obstetric and Perinatal Outcome.Journal of women's health (2002) · 2018Article
- Ovarian and Uterine Functions in Female Survivors of Childhood Cancers.The oncologist · 2018Review
- Pregnancy and Labor Complications in Female Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study.Journal of the National Cancer Institute · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThis study was undertaken to evaluate the effect of prior treatment with radiation therapy or chemotherapy for unilateral Wilms tumor (WT) diagnosed during childhood on pregnancy complications, birth weight, and the frequency of congenital malformations in live-born offspring. PATIENTS AND
methodsWe reviewed pregnancy outcomes among female survivors and partners of male survivors of WT treated on National Wilms Tumor Studies 1, 2, 3, and 4 by using a maternal questionnaire and a review of both maternal and offspring medical records.
resultsWe received reports of 1,021 pregnancies with duration of 20 weeks or longer, including 955 live-born singletons, for whom 700 sets of maternal and offspring medical records were reviewed. Rates of hypertension complicating pregnancy (International Classification of Diseases [ICD] code 642), early or threatened labor (ICD-644) and malposition of the fetus (ICD-652) increased with increasing radiation dose in female patients. The percentages of offspring weighing less than 2,500 g at birth and of those having less than 37 weeks of gestation also increased with dose. There was no significant trend with radiation dose in the number of congenital anomalies recorded in offspring of female patients.
conclusionWomen who receive flank radiation therapy as part of the treatment for unilateral WT are at increased risk of hypertension complicating pregnancy, fetal malposition, and premature labor. The offspring of these women are at risk for low birth weight and premature (ie, < 37 weeks gestation) birth. These risks must be considered in the obstetrical management of female survivors of WT.
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