Trial reportArchives of ophthalmology (Chicago, Ill. : 1960)2010
African Descent and Glaucoma Evaluation Study (ADAGES): III. Ancestry differences in visual function in healthy eyes.
Trial report in Archives of ophthalmology (Chicago, Ill. : 1960), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 93 citations in OpenAlex.
- Prediction accuracy of a novel dynamic structure-function model for glaucoma progression.Investigative ophthalmology & visual science · 2014Trial
- Clinical and demographic characteristics of glaucoma patients in Kingston, Jamaica.International ophthalmology · 2026Article
- "I want to see everything": A community-based participatory research framework to identify eye health and vision care knowledge, perceptions, values, and barriers.Journal of clinical and translational science · 2026Article
- Comparison of Methods for Visual Field Progression in Eyes With Central Visual Field Defects.Translational vision science & technology · 2025Article
- Association Between Optic Nerve Head Prelaminar Schisis and Visual Field Progression in Glaucoma.American journal of ophthalmology · 2025Article
- Medical and surgical treatment management in open angle glaucoma patients of Asian descent: A narrative review.European journal of ophthalmology · 2025Review
- Impact of race and ethnicity on glaucoma progression detection by perimetry and optical coherence tomography.Scientific reports · 2024Article
- Impact of Race and Ethnicity on Glaucoma Progression Detection by Perimetry and Optical Coherence Tomography.Research square · 2024Article
- Progressive Visual Field Loss and Subsequent Quality of Life Outcomes in Glaucoma.American journal of ophthalmology · 2023Article
- Risk factors for structural and functional progression of primary open-angle glaucoma in an African ancestry cohort.BMJ open ophthalmology · 2023Article
- Deep Learning Estimation of 10-2 Visual Field Map Based on Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements.American journal of ophthalmology · 2023Article
- Glaucomatous Visual Field Progression in the African Descent and Glaucoma Evaluation Study (ADAGES): Eleven Years of Follow-up.American journal of ophthalmology · 2022Observational
- Visual Field Progression in Glaucoma: Comparison Between PoPLR and ANSWERS.Translational vision science & technology · 2021Article
- Qualitative Evaluation of the 10-2 and 24-2 Visual Field Tests for Detecting Central Visual Field Abnormalities in Glaucoma.American journal of ophthalmology · 2021Article
- A simplified combined index of structure and function for detecting and staging glaucomatous damage.Scientific reports · 2021Article
- Characterizing and quantifying the temporal relationship between structural and functional change in glaucoma.PloS one · 2021Article
- Evaluation of the external validity of a joint structure-function model for monitoring glaucoma progression.Scientific reports · 2020Article
- Investigation of associations between Piezo1 mechanoreceptor gain-of-function variants and glaucoma-related phenotypes in humans and mice.Scientific reports · 2020Article
- Deep Learning Approaches Predict Glaucomatous Visual Field Damage from OCT Optic Nerve Head En Face Images and Retinal Nerve Fiber Layer Thickness Maps.Ophthalmology · 2020Article
- A framework for assessing glaucoma progression using structural and functional indices jointly.PloS one · 2020Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate differences in visual function between the healthy eyes of people of African (AD) and European descent (ED).
methodsVisual function was assessed in 393 AD and 367 ED participants selected from the African Descent and Glaucoma Evaluation Study and the Diagnostic Innovations in Glaucoma Study. Participants had normal appearance of the optic disc and intraocular pressure of less than 22 mm Hg. Each participant had 2 reliable 24-2 standard automated perimetry tests, and most had short-wavelength automated perimetry and frequency-doubling technology tests. The generalized estimating equation was used to adjust for intereye correlations. Results were adjusted for age, vertical cup-disc ratio, disc size, central corneal thickness, and presence of high blood pressure.
resultsThe AD participants were younger (mean [SD] age, 46.2 [13.2] years) than the ED participants (age, 49.5 [16.6] years) (P = .003). The AD participants had worse mean deviation and pattern standard deviation and more points triggered as abnormal on the total and pattern deviation plots compared with ED participants on all tests (P < .05). A larger percentage of AD participants had confirmed abnormal glaucoma hemifield test results on standard automated perimetry only.
conclusionsPeople of AD have significantly worse performance than people of ED on all tests of visual function. Additional research using longitudinal data is needed to determine the cause of these small but significant ancestry differences in visual function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.