ArticleGenetics2010
Some consequences of demographic stochasticity in population genetics.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Fixation Probabilities of Mutant Alleles in an Ecological Context.bioRxiv : the preprint server for biology · 2026Article
- Population structure reverses selection of variants with proportionally scaled birth and death rates.Nature communications · 2025Article
- Phase separation and coexistence in spatial coordination games between microbes.bioRxiv : the preprint server for biology · 2025Article
- Reproductive variance can drive behavioral dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Stochasticity directs adaptive evolution toward nonequilibrium evolutionary attractors.Ecology · 2023Article
- Evolution in fluctuating environments: A generic modular approach.Evolution; international journal of organic evolution · 2022Article
- Quantifying invasibility.Ecology letters · 2022Article
- Analysis of diversity-dependent species evolution using concepts in population genetics.Journal of mathematical biology · 2021Article
- Understanding the evolution of interspecies interactions in microbial communities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- The Price equation and evolutionary epidemiology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Effects of niche overlap on coexistence, fixation and invasion in a population of two interacting species.Royal Society open science · 2020Article
- A mathematical formalism for natural selection with arbitrary spatial and genetic structure.Journal of mathematical biology · 2019Article
- Fixation probabilities in populations under demographic fluctuations.Journal of mathematical biology · 2018Article
- Effects of demographic stochasticity and life-history strategies on times and probabilities to fixation.Heredity · 2018Article
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- Demographic noise can reverse the direction of deterministic selection.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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- The emergence of cooperation from a single mutant during microbial life cycles.Journal of the Royal Society, Interface · 2015Article
- Non-Selective Evolution of Growing Populations.PloS one · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Much of population genetics is based on the diffusion limit of the Wright-Fisher model, which assumes a fixed population size. This assumption is violated in most natural populations, particularly for microbes. Here we study a more realistic model that decouples birth and death events and allows for a stochastically varying population size. Under this model, classical quantities such as the probability of and time before fixation of a mutant allele can differ dramatically from their Wright-Fisher expectations. Moreover, inferences about natural selection based on Wright-Fisher assumptions can yield erroneous and even contradictory conclusions: at small population densities one allele will appear superior, whereas at large densities the other allele will dominate. Consequently, competition assays in laboratory conditions may not reflect the outcome of long-term evolution in the field. These results highlight the importance of incorporating demographic stochasticity into basic models of population genetics.
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