Evidence map›Paper›PMID 20457867›Full record

ArticleJournal of the National Comprehensive Cancer Network : JNCCN2010

NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.

George D Demetri, Margaret von Mehren, Cristina R Antonescu, Ronald P DeMatteo, Kristen N Ganjoo, Robert G Maki, Peter W T Pisters, Chandrajit P Raut, Richard F Riedel, Scott Schuetze and 3 more

6 registry-linked trialsAbstract readConsensus Statement
In one paragraph

Article in Journal of the National Comprehensive Cancer Network : JNCCN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 507 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
507citing papers in PubMed, 5 pooled it
55.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02260505 phase3completednot on this mapstarted 2014, after this paper: background citation

A Randomized Multicenter Phase III Trial Evaluating the Interest of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)

TypeinterventionalSponsorCentre Leon BerardRan2014 to 2023Enrolled136ConditionsGastrointestinal Stromal Tumors, Resected Gastrointestinal Stromal Tumors, Non-metastatic, High Risk of RecurrenceArmsImatinib maintenance
NCT02662478 completednot on this map

Accuracy and Feasibility of a Morpho-anatomical Classification Oriented Laparoscopic Resection of Gastric Stromal Tumors in Advanced Laparoscopic Surgery Center: a Prospective Cohort Study

TypeobservationalSponsorMedical Park Gaziantep HospitalRan2008 to 2016Enrolled23ConditionsGastrointestinal Stromal TumorsArmsLaparoscopic Surgery
NCT03082079 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Long Outcome of Endoscopic Submucosal Dissection for Small Gastrointestinal Stromal Tumors (<2cm) :a Randomized Controlled Trial

TypeinterventionalSponsorNanfang Hospital, Southern Medical UniversityRan2017 to 2021Enrolled90ConditionsGISTArmsESD
NCT03716089 recruitingnot on this mapstarted 2018, after this paper: background citation

Prospective Controlled Clinical Trial for Comparison of Tumor Efficacy Safety in Laparoscopic Resection of Gastrointestinal Stromal Tumors Between Favorable and Unfavorable Site(FUGES-016)

TypeobservationalSponsorFujian Medical UniversityRan2018 to 2027Enrolled250ConditionsGIST of Stomach, Gastric Cancer, Surgery, ComplicationArmsLaparoscopic resection
NCT04622098 unknown statusnot on this mapstarted 2020, after this paper: background citation

Prevalence of Sub-epithelial Lesions Among Patients Undergoing EGDs in Egypt

TypeobservationalSponsorKafrelsheikh UniversityRan2020 to 2022Enrolled2,000ConditionsEsophageal Neoplasms, Gastric Neoplasm, Duodenal NeoplasmsArmsEndoscopic ultrasound
NCT04751591 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Prospective Randomized Controlled Multicenter Clinical Trial For Comparison Of Safety Between Endoscopic Resection And Laparoscopic Partial Gastrectomy In Patients With 2-5cm Gastric Gastrointestinal Stromal Tumor

TypeinterventionalSponsorShanghai Zhongshan HospitalRan2021 to 2024Enrolled260ConditionsGastric GISTArmsEndoscopic resection, Laparoscopic partial gastrectomy
3 · Its place in the literature

Who cites it

507 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,215 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. LAPAROSCOPIC VERSUS OPEN SURGERY IN GASTRIC GASTROINTESTINAL STROMAL TUMORS LARGER THAN 5 CM: A SYSTEMATIC REVIEW AND META-ANALYSIS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2023
    Pooled it
  4. Pooled it
  5. Pooled it
  6. FDA Approval Summary: Ripretinib for Advanced Gastrointestinal Stromal Tumor.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Trial
  7. Avapritinib Versus Regorafenib in Locally Advanced Unresectable or Metastatic GI Stromal Tumor: A Randomized, Open-Label Phase III Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

447 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

George D DemetriLudwig Center at Dana-Farber/Harvard Cancer Center, USA.
Margaret von Mehren
Cristina R Antonescu
Ronald P DeMatteo
Kristen N Ganjoo
Robert G Maki
Peter W T Pisters
Chandrajit P Raut
Richard F Riedel
Scott Schuetze
Hema M Sundar
Jonathan C Trent
Jeffrey D Wayne
Palmetto Hematology Oncology · USSociety of Surgical Oncology · US

Funding

Molecular Mechanisms in Gastrointestinal Stromal TumorR01CA102613 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ronald P. Dematteo · 2004 to 2026
$9.2M
The Molecular Actions of Imatinib Mesylate in GISTsR01CA106588 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GODWIN, ANDREW K., VON MEHREN, MARGARET · 2004 to 2013
$3.8M
NCI NIH HHS R01 CA102613NCI NIH HHS R01 CA106588
6 · The paper itself

Abstract

The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of effective molecularly targeted therapies involving tyrosine kinase inhibitors (TKIs), such as imatinib mesylate and sunitinib malate. A better understanding of the molecular characteristics of GISTs have improved the diagnostic accuracy and led to the discovery of novel immunomarkers and new mechanisms of resistance to TKI therapy, which in turn have resulted in the development of novel treatment strategies. To address these issues, the NCCN organized a task force consisting of a multidisciplinary panel of experts in the fields of medical oncology, surgical oncology, molecular diagnostics, and pathology to discuss the recent advances, identify areas of future research, and recommend an optimal approach to care for patients with GIST at all stages of disease. The task force met for the first time in October 2003 and again in December 2006 and October 2009. This supplement describes the recent developments in the field of GIST as discussed at the October 2009 meeting.

Indexed as

Antineoplastic AgentsBenzamidesBiomarkers, TumorDiagnostic ImagingDNA Mutational AnalysisGastrointestinal Stromal TumorsGene Expression ProfilingHumansImatinib MesylateIndolesPiperazinesPrognosisPyrimidinesPyrrolesSunitinibAntineoplastic AgentsBenzamidesBiomarkers, TumorImatinib MesylateIndolesPiperazinesPyrimidinesPyrrolesSunitinib

Identifiers

PMID20457867
PMCPMC4103754
OpenAlexW2123232650

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.