ArticleJournal of neurophysiology2010
Retinal synaptic pathways underlying the response of the rabbit local edge detector.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Surround motion modulates the encoding properties of primate retinal ganglion cells.Cell reports · 2026Article
- Defining morphologically and genetically distinct GABAergic/cholinergic amacrine cell subtypes in the vertebrate retina.PLoS biology · 2024Article
- Evolution of Brains and Computers: The Roads Not Taken.Entropy (Basel, Switzerland) · 2022Article
- Visual properties of human retinal ganglion cells.PloS one · 2021Article
- Inhibitory components of retinal bipolar cell receptive fields are differentially modulated by dopamine D1 receptors.Visual neuroscience · 2020Article
- Evolutionary aspects of reservoir computing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Synaptic Contributions to Receptive Field Structure and Response Properties in the Rodent Lateral Geniculate Nucleus of the Thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling.Journal of neurophysiology · 2016Article
- Functional Circuitry of the Retina.Annual review of vision science · 2015Article
- The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.PLoS genetics · 2015Article
- High Accuracy Decoding of Dynamical Motion from a Large Retinal Population.PLoS computational biology · 2015Article
- Article
- Broad thorny ganglion cells: a candidate for visual pursuit error signaling in the primate retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- GABAergic neurotransmission and retinal ganglion cell function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Response Properties of a Newly Identified Tristratified Narrow Field Amacrine Cell in the Mouse Retina.PloS one · 2015Article
- GlyRα2, not GlyRα3, modulates the receptive field surround of OFF retinal ganglion cells.Visual neuroscience · 2015Article
- Adeno-associated virus-RNAi of GlyRα1 and characterization of its synapse-specific inhibition in OFF alpha transient retinal ganglion cells.Journal of neurophysiology · 2014Article
- Article
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2 authors.
Funding
Abstract
We studied the circuitry that underlies the behavior of the local edge detector (LED) retinal ganglion cell in rabbit by measuring the spatial and temporal properties of excitatory and inhibitory currents under whole cell voltage clamp. Previous work showed that LED excitation is suppressed by activity in the surround. However, the contributions of outer and inner retina to this characteristic and the neurotransmitters used are currently unknown. Blockage of retinal inhibitory pathways (GABA(A), GABA(C), and glycine) eliminated edge selectivity. Inverting gratings in the surround with 50-microm stripe sizes did not stimulate horizontal cells, but suppressed on and off excitation by roughly 60%, indicating inhibition of bipolar terminals (feedback inhibition). On pharmacologic blockage, we showed that feedback inhibition used both GABA(A) and GABA(C) receptors, but not glycine. Glycinergic inhibition suppressed GABAergic feedback inhibition in the center, enabling larger excitatory currents in response to luminance changes. Excitation, feedback inhibition, and direct (feedforward) inhibition responded to luminance-neutral flipping gratings of 20- to 50-microm widths, showing they are driven by independent subunits within their receptive fields, which confers sensitivity to borders between areas of texture and nontexture. Feedforward inhibition was glycinergic, its rise time was faster than decay time, and did not function to delay spiking at the onset of a stimulus. Both the on and off phases could be triggered by luminance shifts as short in duration as 33 ms and could be triggered during scenes that already produced a high baseline level of feedforward inhibition. Our results show how LED circuitry can use subreceptive field sensitivity to detect visual edges via the interaction between excitation and feedback inhibition and also respond to rapid luminance shifts within a rapidly changing scene by producing feedforward inhibition.
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