Evidence map›Paper›PMID 20457462›Full record

ArticleVirology2010

Characterization of the gene expression profile of human bocavirus.

Aaron Yun Chen, Fang Cheng, Sai Lou, Yong Luo, Zhengwen Liu, Eric Delwart, David Pintel, Jianming Qiu

Open access · greenAbstract readComparative Study
In one paragraph

Article in Virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 119 citations in OpenAlex.

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  12. Viral Respiratory Pathogens and Lung Injury.Clinical microbiology reviews · 2021
    Review
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Aaron Yun ChenDepartment of Microbiology, University of Kansas Medical Center, Kansas City, KS, USA.
Fang Cheng
Sai Lou
Yong Luo
Zhengwen Liu
Eric Delwart
David Pintel
Jianming Qiu
University of Kansas Medical Center · USFirst Affiliated Hospital of Xi'an Jiaotong University · CNSystems Research Institute · PLUniversity of Missouri · US

Funding

XRAY CRYSTALLOGRAPHY CORE (JANUARY 1 - JUNE 30, 2005)P20RR016443 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI VINES, CHARLOTTE M · 2001 to 2010
$21.3M
Parvovirus RNA Processing and Gene Expression StrategiesR01AI046458 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI PINTEL, DAVID J. · 2000 to 2018
$4.6M
Post-Transcriptional Regulation of Parvovirus Capsid Gene ExpressionR01AI070723 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2007 to 2017
$3.3M
MOLECULAR &GENETIC ANALYSIS OF MVM GENE EXPRESSIONR01AI021302 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI PINTEL, DAVID J. · 1985 to 2008
$2.4M
Parvovirus RNA Processing and Gene Expression StrategiesR56AI046458 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI PINTEL, DAVID J. · 2013 to 2013
$374k
NCRR NIH HHS P20 RR016443NIAID NIH HHS AI21302NIAID NIH HHS AI46458NIAID NIH HHS R01 AI021302NIAID NIH HHS R01 AI046458NIAID NIH HHS R01 AI070723NIAID NIH HHS R56 AI046458
6 · The paper itself

Abstract

We have generated a quantitative transcription profile of human bocavirus type 1 (HBoV1) by transfecting a nearly full-length clone in human lung epithelial A549 cells as well as in a replication competent system in 293 cells. The overall transcription profile of HBoV1 is similar to that of two other members of genus Bocavirus, minute virus of canines and bovine parvovirus 1. In particular, a spliced NS1-transcript that was not recognized previously expressed the large non-structural protein NS1 at approximately 100kDa; and the NP1-encoding transcripts were expressed abundantly. In addition, the protein expression profile of human bocavirus type 2 (HBoV2) was examined in parallel by transfection of a nearly full-length clone in A549 cells, which is similar to that of HBoV1. Moreover, our results showed that, unlike human parvovirus B19 infection, expression of the HBoV1 proteins only does not induce cell cycle arrest and apoptosis of A549 cells.

Indexed as

Gene Expression ProfilingBocavirusCell LineHuman bocavirusHumansRNA, MessengerRNA SplicingRNA, ViralRNA, MessengerRNA, Viral

Identifiers

PMID20457462
PMCPMC2879452
OpenAlexW2028968006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.