ArticleDevelopmental biology2010
Functional characterization of bursicon receptor and genome-wide analysis for identification of genes affected by bursicon receptor RNAi.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Up-regulation of Minibrain/DYRK1A contributes to macrocephaly and brain overgrowth in aProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neuropeptide Bursicon and its receptor-mediated the transition from summer-form to winter-form ofeLife · 2024Article
- RNAi turns 25:contributions and challenges in insect science.Frontiers in insect science · 2023Review
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- G-Protein Coupled Receptors (GPCRs): Signaling Pathways, Characterization, and Functions in Insect Physiology and Toxicology.International journal of molecular sciences · 2021Review
- Identification and Expression Analysis of G Protein-Coupled Receptors in the Miridae InsectFrontiers in endocrinology · 2021Article
- Neuropeptide Bursicon Influences Reproductive Physiology inFrontiers in physiology · 2021Article
- The tanning hormone, bursicon, does not act directly on the epidermis to tan the Drosophila exoskeleton.BMC biology · 2020Article
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- A morphological novelty evolved by co-option of a reduced gene regulatory network and gene recruitment in a beetle.Proceedings. Biological sciences · 2018Article
- Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development.Environmental science & technology · 2017Review
- Relish2 mediates bursicon homodimer-induced prophylactic immunity in the mosquito Aedes aegypti.Scientific reports · 2017Article
- RNAi-Mediated Functional Analysis of Bursicon Genes Related to Adult Cuticle Formation and Tanning in the Honeybee, Apis mellifera.PloS one · 2016Article
- Membrane tethered bursicon constructs as heterodimeric modulators of the Drosophila G protein-coupled receptor rickets.Molecular pharmacology · 2013Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bursicon is an insect neuropeptide hormone that is secreted from the central nervous system into the hemolymph and initiates cuticle tanning. The receptor for bursicon is encoded by the rickets (rk) gene and belongs to the G protein-coupled receptor (GPCR) superfamily. The bursicon and its receptor regulate cuticle tanning as well as wing expansion after adult eclosion. However, the molecular action of bursicon signaling remains unclear. We utilized RNA interference (RNAi) and microarray to study the function of the bursicon receptor (Tcrk) in the model insect, Tribolium castaneum. The data included here showed that in addition to cuticle tanning and wing expansion reported previously, Tcrk is also required for development and expansion of integumentary structures and adult eclosion. Using custom microarrays, we identified 24 genes that are differentially expressed between Tcrk RNAi and control insects. Knockdown in the expression of one of these genes, TC004091, resulted in the arrest of adult eclosion. Identification of genes that are involved in bursicon receptor mediated biological processes will provide tools for future studies on mechanisms of bursicon action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.