Evidence map›Paper›PMID 20456938›Full record

ReviewCurrent opinion in genetics & development2010

The inherited genetics of ovarian and endometrial cancer.

Simon A Gayther, Paul D P Pharoah

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Guideline
  2. ASSOCIATION OF MTHFR A1298C POLYMORPHISM WITH BREAST CANCER AND/OR OVARIAN CANCER RISK: AN UPDATED META-ANALYSIS.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2016
    Pooled it
  3. Quantitative assessment of the association between CYP1A1 A4889G polymorphism and endometrial cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013
    Pooled it
  4. Article
  5. Article
  6. Predictive Genetic Testing in the Cancer Management and Prevention.Journal of cancer science and clinical therapeutics · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Epidemiology and risk factors for ovarian cancer.Przeglad menopauzalny = Menopause review · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Curcumin and endometrial carcinoma: an old spice as a novel agent.International journal of women's health · 2019
    Review
  20. Epigenetics in ovarian cancer.Seminars in cancer biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Simon A GaytherEGA Institute for Women's Health, Gynaecological Cancer Research Laboratories, University College London, London, UK. s.gayther@ucl.ac.uk
Paul D P Pharoah
University College London · GBUniversity of Cambridge · GB

Funding

Cancer Research UK 10119Cancer Research UK A10119
6 · The paper itself

Abstract

Endometrial and epithelial ovarian cancers are the fourth and fifth most common cancers in women in developed countries, after breast, lung, and colorectal cancer. In the United States alone, in 2008 there were about 40,000 new diagnoses of endometrial cancer and 7500 disease-related deaths. For ovarian cancer, there were about 22,000 new diagnoses and 15,000 deaths over the same period. The purpose of this article is to review the recent developments in the inherited genetics of ovarian and endometrial cancer, with particular attention to recent progress in identifying common low-penetrance susceptibility genes and their clinical implications.

Indexed as

Endometrial NeoplasmsFamily HealthFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansOvarian NeoplasmsPenetrancePolymorphism, Single NucleotideRisk Factors

Identifiers

PMID20456938
PMCPMC3073171
OpenAlexW1986210682

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.