Evidence map›Paper›PMID 20456657›Full record

ArticlePsychophysiology2010

Neuronal generator patterns of olfactory event-related brain potentials in schizophrenia.

Jürgen Kayser, Craig E Tenke, Dolores Malaspina, Christopher J Kroppmann, Jennifer D Schaller, Andrew Deptula, Nathan A Gates, Jill M Harkavy-Friedman, Roberto Gil, Gerard E Bruder

Abstract read
In one paragraph

Article in Psychophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2015
    Review
  7. Olfaction in the psychosis prodrome: electrophysiological and behavioral measures of odor detection.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2013
    Article
  8. Generator localization by current source density (CSD): implications of volume conduction and field closure at intracranial and scalp resolutions.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jürgen KayserDivision of Cognitive Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA. kayserj@pi.cpmc.columbia.edu
Craig E Tenke
Dolores Malaspina
Christopher J Kroppmann
Jennifer D Schaller
Andrew Deptula
Nathan A Gates
Jill M Harkavy-Friedman
Roberto Gil
Gerard E Bruder

Funding

Subtypes of Schizophrenia: ERPs During Memory ProcessingR01MH066597 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BRUDER, GERARD E · 2004 to 2008
$1.8M
Olfactory and Social Function in SchizophreniaR01MH066428 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MALASPINA, DOLORES · 2004 to 2007
$1.8M
Olfaction and Emotion in Depression: Behavioral Electrodermal and ERP MeasuresR21MH082393 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KAYSER, RALF JÜRGEN · 2008 to 2009
$396k
NIMH NIH HHS MH066428NIMH NIH HHS MH066597NIMH NIH HHS MH082393NIMH NIH HHS R01 MH066428NIMH NIH HHS R01 MH066597NIMH NIH HHS R21 MH082393
6 · The paper itself

Abstract

To better characterize neurophysiologic processes underlying olfactory dysfunction in schizophrenia, nose-referenced 30-channel electroencephalogram was recorded from 32 patients and 35 healthy adults (18 and 18 male) during detection of hydrogen sulfide (constant-flow olfactometer, 200 ms unirhinal exposure). Event-related potentials (ERPs) were transformed to reference-free current source density (CSD) waveforms and analyzed by unrestricted Varimax-PCA. Participants indicated when they perceived a high (10 ppm) or low (50% dilution) odor concentration. Patients and controls did not differ in detection of high (23% misses) and low (43%) intensities and also had similar olfactory ERP waveforms. CSDs showed a greater bilateral frontotemporal N1 sink (305 ms) and mid-parietal P2 source (630 ms) for high than low intensities. N1 sink and P2 source were markedly reduced in patients for high intensity stimuli, providing further neurophysiological evidence of olfactory dysfunction in schizophrenia.

Indexed as

Schizophrenic PsychologyAdolescentAdultAnalysis of VarianceArtifactsData Interpretation, StatisticalElectroencephalographyEvoked PotentialsFemaleHumansHydrogen SulfideMaleMiddle AgedOdorantsOlfaction DisordersPrincipal Component AnalysisHydrogen Sulfide

Identifiers

PMID20456657
PMCPMC3341093

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.