Trial reportInternational wound journal2010
Allogenic platelet gel in the treatment of pressure sores: a pilot study.
Trial report in International wound journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Efficacy and safety of allogeneic platelet-rich plasma in chronic wound treatment: a meta-analysis of randomized controlled trials.Scientific reports · 2024Pooled it
- Reconstructive surgery for treating pressure ulcers.The Cochrane database of systematic reviews · 2022Pooled it
- Dressings and topical agents for treating pressure ulcers.The Cochrane database of systematic reviews · 2017Pooled it
- Reconstructive surgery for treating pressure ulcers.The Cochrane database of systematic reviews · 2016Pooled it
- Autologous platelet-rich plasma for treating chronic wounds.The Cochrane database of systematic reviews · 2016Pooled it
- Blood derivatives as monotherapy and combination therapy: A promising strategy for wound healing.Regenerative therapy · 2025Review
- "Platelet-Rich Fibrin Membrane-as a novel biomaterial for pressure injury healing in a person with spinal cord injury: A case report".Spinal cord series and cases · 2022Article
- The role of allogeneic platelet-rich plasma in patients with diabetic foot ulcer: Current perspectives and future challenges.Frontiers in bioengineering and biotechnology · 2022Review
- Healing of Chronic Wounds with Platelet-Derived Growth Factors from Single Donor Platelet-Rich Plasma following One Freeze-Thaw Cycle. A Cross-Sectional Study.Journal of clinical medicine · 2021Article
- Efficacy of Local Autologous Platelet-Rich Plasma in the Treatment of Pressure Ulcer in Spinal Cord Injury Patients.Cureus · 2021Article
- Cellular Response to Individual Components of the Platelet Concentrate.International journal of molecular sciences · 2021Article
- Platelet Rich Plasma Enhancement of Skin Regeneration in anFrontiers in bioengineering and biotechnology · 2019Article
- The Lipid Portion of Activated Platelet-Rich Plasma Significantly Contributes to Its Wound Healing Properties.Advances in wound care · 2015Article
- Combined use of super-oxidised solution with negative pressure for the treatment of pressure ulcers: case report.International wound journal · 2013Article
- A preliminary study on the potential of manuka honey and platelet-rich plasma in wound healing.International journal of biomaterials · 2012Article
- Incorporating platelet-rich plasma into electrospun scaffolds for tissue engineering applications.Tissue engineering. Part A · 2011Article
- Effect of platelet rich plasma gel in a physiologically relevant platelet concentration on wounds in persons with spinal cord injury.International wound journal · 2011Article
- Use of platelet rich plasma gel on wound healing: a systematic review and meta-analysis.Eplasty · 2011Article
- Comparison of Allogeneic Platelet-rich Plasma With Autologous Platelet-rich Plasma for the Treatment of Diabetic Lower Extremity Ulcers.Cell transplantationArticle
- ALLOGENEIC PLATELET-RICH PLASMA FOR ROTATOR CUFF REPAIR.Acta ortopedica brasileiraArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although platelet gel is considered one of the most popular tools in the treatment of chronic ulcers, current consensus on its use is not unanimous. A prospective randomised trial was carried out at the Plastic Surgery Unit of the 'Salvatore Maugeri' Foundation Hospital of Pavia (Italy). The study involved 13 patients affected by spinal cord injury with 16 pressure sores over a period of 20 months. The ulcer was considered the experimental unit of the study irrespective of the number of ulcers per patient. Each consecutive ulcer was randomised to be treated either with allogenic platelet gel or with current best practice approach to chronic wounds dressing protocol. At the end of the treatment 15 ulcers out of 16 improved clinically. No statistically significant difference was demonstrated in volume reduction between the two groups, although a statistically significant difference could be demonstrated in the onset time of granulation tissue proliferation as in the wounds treated with platelet gel the healing process was triggered earlier. Our study suggests that platelet gel is mostly effective within the first 2 weeks of treatment while a prolonged treatment does not provide any significant advantage versus the current best practice approach to chronic wounds protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.