ArticleGenes, brain, and behavior2010
Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression.
Article in Genes, brain, and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Psychological Mediators of the Association Between Childhood Emotional Abuse and Depression: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Article
- Adults with Autism and Adults with Depression Show Similar Attentional Biases to Social-Affective Images.Journal of autism and developmental disorders · 2020Article
- Rumination impairs the control of stimulus-induced retrieval of irrelevant information, but not attention, control, or response selection in general.Psychological research · 2020Article
- Genome-wide association analysis reveals KCTD12 and miR-383-binding genes in the background of rumination.Translational psychiatry · 2019Article
- Associations Among Depressive Symptoms, Childhood Abuse, Neuroticism, Social Support, and Coping Style in the Population Covering General Adults, Depressed Patients, Bipolar Disorder Patients, and High Risk Population for Depression.Frontiers in psychology · 2019Article
- Childhood Adversity Moderates the Effects ofFrontiers in psychiatry · 2019Article
- Early life stress predicts negative urgency through brooding, depending on 5-HTTLPR genotype: A pilot study with 6-month follow-up examining suicide ideation.Psychiatry research · 2017Article
- Cognitive Reactivity: Cultural Adaptation and Psychometric Testing of the Persian Version of the Leiden Index of Depression Sensitivity Revised (LEIDS-R) in an Iranian Sample.International journal of mental health and addiction · 2017Article
- The Serotonin Transporter Promoter Variant, Stress, and Attentional Biases in Middle Childhood.Personality and individual differences · 2016Article
- Empathy as a "risky strength": a multilevel examination of empathy and risk for internalizing disorders.Development and psychopathology · 2014Review
- Associations between the SS variant of 5-HTTLPR and PTSD among adults with histories of childhood emotional abuse: results from two African American independent samples.Journal of affective disorders · 2014Article
- Stressful life events and depression symptoms: the effect of childhood emotional abuse on stress reactivity.Journal of clinical psychology · 2014Article
- A Preliminary Examination of the Relationship Between thePsychological trauma : theory, research, practice and policy · 2014Article
- Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy.Experimental brain research · 2013Review
- Cognitive reactivity, implicit associations, and the incidence of depression: a two-year prospective study.PloS one · 2013Article
- Toward an integration of cognitive and genetic models of risk for depression.Cognition & emotion · 2013Review
- The effects of MAOA genotype, childhood trauma, and sex on trait and state-dependent aggression.Brain and behavior · 2012Article
- Serotonin transporter gene polymorphism and psychiatric disorders: is there a link?Indian journal of psychiatry · 2011Article
- 5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination.Genes, brain, and behavior · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meta-analyses evaluating the association between the serotonin transporter polymorphism (5-HTTLPR) with neuroticism and depression diagnosis as phenotypes have been inconclusive. We examined a gene-environment interaction on a cognitive vulnerability marker of depression, cognitive reactivity (CR) to sad mood. A total of 250 university students of European ancestry were genotyped for the 5-HTTLPR, including SNP rs25531, a polymorphism of the long allele. Association analysis was performed for neuroticism, CR and depression diagnosis (using a self-report measure). As an environmental pathogen, self-reported history of childhood emotional abuse was measured because of its strong relationship with depression. Participants with the homozygous low expressing genotype had high CR if they had experienced childhood emotional maltreatment but low CR if they did not have such experience. This interaction was strongest on the Rumination subscale of the CR measure. The interaction was not significant with neuroticism or depression diagnosis as outcome measures. Our results show that 5-HTTLPR is related to cognitive vulnerability to depression. Our findings provide evidence for a differential susceptibility genotype rather than a vulnerability genotype, possibly because of the relatively low levels of abuse in our sample. The selection of phenotype and environmental contributor is pivotal in investigating gene-environment interactions in psychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.