ArticleOmics : a journal of integrative biology2010
Gene expression profiling of breast cancer cell lines in response to soy isoflavones using a pangenomic microarray approach.
Article in Omics : a journal of integrative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Exploring the Complex Mechanisms of Isoflavones: From Cell Bioavailability, to Cell Dynamics and Breast Cancer.Phytotherapy research : PTR · 2025Review
- A Meta-analysis of Transcriptome Data to Investigate the Effect of Soy Isoflavones on Breast Cancer Cell.Iranian journal of biotechnology · 2024Article
- Targeting Cytochrome P450 Enzymes in Ovarian Cancers: New Approaches to Tumor-Selective Intervention.Biomedicines · 2023Review
- Estrogenic in vitro evaluation of zearalenone and its phase I and II metabolites in combination with soy isoflavones.Archives of toxicology · 2022Article
- Article
- Genistein: is the multifarious botanical a natural anthelmintic too?Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Article
- In Vitro Estrogenic and Breast Cancer Inhibitory Activities of Chemical Constituents Isolated from Rheum undulatum L.Molecules (Basel, Switzerland) · 2018Article
- Predictors of breast cancer cell types and their prognostic power in breast cancer patients.BMC genomics · 2018Article
- The Impact of Soy Isoflavones on MCF-7 and MDA-MB-231 Breast Cancer Cells Using a Global Metabolomic Approach.International journal of molecular sciences · 2016Article
- Article
- Soy Isoflavones and Breast Cancer Cell Lines: Molecular Mechanisms and Future Perspectives.Molecules (Basel, Switzerland) · 2015Review
- Collagen density regulates xenobiotic and hypoxic response of mammary epithelial cells.Environmental toxicology and pharmacology · 2015Article
- Coexposure to phytoestrogens and bisphenol a mimics estrogenic effects in an additive manner.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- The small molecule, genistein, increases hepcidin expression in human hepatocytes.Hepatology (Baltimore, Md.) · 2013Article
- The estrogenic content of rodent diets, bedding, cages, and water bottles and its effect on bisphenol A studies.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Review
- Article
- Does consuming isoflavones reduce or increase breast cancer risk?Genome medicine · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the rate of breast cancer differs between women in Asian and Western countries, molecular genetics/genomics basis of this epidemiological observation remains elusive. Moreover, the intake of phytoestrogens is associated with a lower incidence of breast cancer. Genistein and daidzein are the primary soy isoflavones with a chemical structure similar to estrogens. Conceivably, the actions of phytoestrogens on gene expression signatures might mediate their postulated effects on breast cancer pathogenesis. The present study evaluated the transcriptional responsiveness of breast cancer cells to soy phytoestrogens using a whole-genome microarray-based approach. Human breast cancer cell lines and a fibrocystic breast cell line were treated with genistein or daidzein. We identified 278 and 334 differentially expressed genes after genistein or daidzein treatment, respectively, in estrogen-positive (MCF-7) and estrogen-negative (MDA-MB-231, MCF-10a) cells. Hierarchical clustering of this finding revealed a significant modulation, respectively, of 246 or 169 genes after genistein or daidzein exposures. Importantly, the molecular pathways for the differentially expressed genes included those that relate to cell communication, biodegradation of xenobiotics, lipid metabolism, signal transduction, and cell growth/death. These molecular observations collectively contribute to a growing knowledgebase on the putative mechanism(s) of action of phytoestrogens in breast cancer pathogenesis and chemoprevention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.