SynthesisHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme2010
Depression and osteoporosis: a research synthesis with meta-analysis.
Synthesis in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years.Frontiers in physiology · 2023Pooled it
- The Use of Antidepressive Agents and Bone Mineral Density in Women: A Meta-Analysis.International journal of environmental research and public health · 2018Pooled it
- Bone Density and Fractures in HIV-infected Postmenopausal Women: A Systematic Review.The Journal of the Association of Nurses in AIDS Care : JANACPooled it
- Do premenopausal women with major depression have low bone mineral density? A 36-month prospective study.PloS one · 2012Trial
- Trial
- Pulsed electromagnetic fields activate a peripheral interoceptive pathway to suppress sympathetic Npy for osteogenesis.Nature communications · 2026Article
- Construction and Validation of Plasma Protein-Based Musculoskeletal Biological Age and Genetic and Environmental Risk Profiles.Aging cell · 2026Article
- Effect of Social Support Reciprocity on Mental Health Status Among Community-Dwelling Older Adults: A Cross-Sectional Study of the Kashiwa Cohort Study.Health science reports · 2026Article
- The brain-bone-gut axis: a microbial bridge underlying multisystem comorbidities.Frontiers in endocrinology · 2026Review
- Brain-bone axis dysregulation: Biological code underlying the bidirectional association between depression and musculoskeletal disorders.Journal of orthopaedic translation · 2026Review
- Psychosomatic interplay in postmenopausal osteoporosis: from neuroendocrine mechanisms to structured psychological therapies and long-term management.Frontiers in psychiatry · 2026Review
- The association of loneliness with bone mineral density, osteoporosis, osteopenia, fall, and sarcopenia among older adults: results from Mr. and Ms. Os (Hong Kong) study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Evaluation of PTSD-Induced Alterations in Bone Biomechanics and the Protective Potential of CE-123 in a Wistar Rat Model.Journal of clinical medicine · 2025Article
- Effect of RANKL on Lower Depressive Symptoms In Hemodialysis Patients.Calcified tissue international · 2024Article
- Psychological Disorders Linked to Osteoporosis Diagnoses in a Population-Based Cohort Study of Middle and Older Age United States Adults.The Gerontologist · 2024Article
- Shared genetic architecture highlights the bidirectional association between major depressive disorder and fracture risk.General psychiatry · 2024Article
- The effect of serum calcium on the association of depression with infertility among U.S. women.Heliyon · 2023Article
- Major depressive disorders in patients with inflammatory bowel disease and rheumatoid arthritis.World journal of clinical cases · 2023Article
- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
- Impact of seborrheic dermatitis on osteoporosis risk: A population-based cohort study.The Journal of dermatology · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Major depressive disorder has been associated with low bone mineral density. The strength of this association, however, varies greatly among studies; the direction of the causative link is still controversial, and the etiology remains unclear. We aimed to confirm this association, assess its magnitude and estimate its clinical relevancy. A total of 535 articles were initially identified and the research synthesis was based on 33 qualified articles. Of these, 25 articles (or 76%) showed an inverse relationship between major depression or minor depression or depressive symptoms and bone mineral density or bone turnover. Meta-analysis could be performed on 20 of the initially selected 33 articles. Standardized weighted differences in mean AP spine, total femur and femoral neck bone mineral density, each from at least 10 studies, were computed in g/cm (2) and transformed into percent differences. At each site, bone mass was lower in subjects with depression as compared to controls: AP spine bone mineral density was 4.73% lower (95% CI -7.28% to -2.19%, p<0.0001; n=16 studies), total femur bone mineral density was 3.53% lower (95% CI -5.66% to -1.41%, p<0.001; n=13 studies), and femoral neck bone mineral density was 7.32% lower (95% CI -10.67% to -3.96%; p<0.0005; n=8 studies). In conclusion, major depressive disorder was associated with lower bone mineral density at the AP spine, femoral neck, and total femur. The deficits in bone mineral density in subjects with depression are of clinical significance and likely to increase fracture risk over the lifetime of these subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.