ReviewCellular and molecular life sciences : CMLS2010
Structure and function of interleukin-22 and other members of the interleukin-10 family.
Review in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Article
- Multifaceted Roles of IL-26 in Physiological and Pathological Conditions.International journal of molecular sciences · 2025Review
- A Phylogenetic Perspective on the Evolutionary Patterns of the Animal Interleukin-10 Signaling System.Genes · 2025Article
- Alloferon and IL-22 receptor expression regulation on the pathogenesis of imiquimod-induced psoriasis.Scientific reports · 2025Article
- An assembled molecular signaling map of interleukin-24: a resource to decipher its multifunctional immunoregulatory role in pathophysiological conditions.Frontiers in immunology · 2025Article
- IL-22 signaling promotes sorafenib resistance in hepatocellular carcinoma via STAT3/CD155 signaling axis.Frontiers in immunology · 2024Article
- TYK2 in Immune Responses and Treatment of Psoriasis.Journal of inflammation research · 2022Review
- JAK-Inhibitors for the Treatment of Rheumatoid Arthritis: A Focus on the Present and an Outlook on the Future.Biomolecules · 2020Review
- The Role of Structure in the Biology of Interferon Signaling.Frontiers in immunology · 2020Review
- Participation of the IL-10RB Related Cytokines, IL-22 and IFN-λ in Defense of the Airway Mucosal Barrier.Frontiers in cellular and infection microbiology · 2020Review
- Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy.Journal of immunology research · 2018Article
- Comparison of the pathogen species-specific immune response in udder derived cell types and their models.Veterinary research · 2016Article
- The Role of Interleukin-22 and Its Receptor in the Development and Pathogenesis of Experimental Autoimmune Uveitis.PloS one · 2016Article
- Impact of the New Generation Reconstituted Surfactant CHF5633 on Human CD4+ Lymphocytes.PloS one · 2016Article
- The molecular basis of IL-10 function: from receptor structure to the onset of signaling.Current topics in microbiology and immunology · 2014Review
- A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.Nature genetics · 2013Article
- Article
- IL-22 is expressed by the invasive trophoblast of the equine (Equus caballus) chorionic girdle.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Myeloid cells migrate in response to IL-24.Cytokine · 2011Article
- In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression.Hepatology (Baltimore, Md.) · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The IL-10 family of cytokines is comprised of IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and IFN-lambdas (IL-28A, IL-28B, and IL-29). The IL-10 family members bind to shared class II cytokine receptor chains that associate in various combinations in heterodimeric complexes. Upon interleukin/receptor complex formation, these proteins switch on the Jak/STAT pathway and elicit pleiotropic biological responses whose variety sharply contrasts with their structural similarities. IL-10 family members are involved in several human diseases and health conditions and hence their structural analyses may provide valuable information to design specific therapeutic strategies. In this review, we describe the human interleukin-10 family of cytokines, focusing on their structures and functions, with particular attention given to IL-22 and IL-10. We report on the recently published structures of IL-10 cytokine family members and their complexes with cognate transmembrane and soluble receptors as well as on interleukin physiology and physiopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.