ArticlePsychopharmacology2010
Measuring anxiety- and locomotion-related behaviours in mice: a new way of using old tests.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 86 citations in OpenAlex.
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- Zebrafish, a biological model for pharmaceutical research for the management of anxiety.Molecular biology reports · 2023Review
- Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder.Neuropharmacology · 2023Review
- Can anxiety-like behavior and spatial memory predict the extremes of skilled walking performance in mice? An exploratory, preliminary study.Frontiers in behavioral neuroscience · 2023Article
- A modified mouse model for observational fear learning and the influence of social hierarchy.Frontiers in behavioral neuroscience · 2022Article
- RGS14 modulates locomotor behavior and ERK signaling induced by environmental novelty and cocaine within discrete limbic structures.Psychopharmacology · 2021Article
- Impairment in locomotor activity as an objective measure of pain and analgesia in a rat model of osteoarthritis.Experimental and therapeutic medicine · 2020Article
- A Review of Behavioral Tests to Evaluate Different Types of Anxiety and Anti-anxiety Effects.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Review
- Computer Methods for Automatic Locomotion and Gesture Tracking in Mice and Small Animals for Neuroscience Applications: A Survey.Sensors (Basel, Switzerland) · 2019Review
- Chemogenetic activation of orexin/hypocretin neurons ameliorates aging-induced changes in behavior and energy expenditure.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Bidirectional Control of Anxiety-Related Behaviors in Mice: Role of Inputs Arising from the Ventral Hippocampus to the Lateral Septum and Medial Prefrontal Cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Article
- Role of prefrontal 5-HT in the strain-dependent variation in sign-tracking behavior of C57BL/6 and DBA/2 mice.Psychopharmacology · 2016Article
- Perinatal vs genetic programming of serotonin states associated with anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Association of brain immune genes with social behavior of inbred mouse strains.Journal of neuroinflammation · 2015Article
- Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders.Behavioural brain research · 2015Article
- Exploring Female Mice Interstrain Differences Relevant for Models of Depression.Frontiers in behavioral neuroscience · 2015Article
- Manual versus automated blood sampling: impact of repeated blood sampling on stress parameters and behavior in male NMRI mice.Laboratory animals · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleBatteries of tests that are thought to measure different aspects of anxiety-related behaviour are used to characterise mice after genetic or pharmacological manipulation. However, because of the potentially confounding effects of repeated testing and natural intra-individual variations in behaviour over time, subjecting mice to a succession of tests is not ideal.
objectivesThe aim of this study was to investigate, in mice, the utility of an integrated apparatus that combines three classical tests of anxiety, the open field, elevated plus maze (EPM) and light/dark box.
methodsMice from four different strains (CD-1, BALB/cJ, DBA/2J, C57BL/6J) were used in a series of five experiments where their behaviour was observed for 15 min in the integrated apparatus. Responses to anxiety-modulating drugs and 2-day repeated testing were evaluated.
resultsCD-1 mice explored the apparatus thoroughly, providing measures from all areas throughout the entire testing session. Factor analysis showed that measures of locomotion and anxiety-related behaviour were dissociable. BALB/cJ, DBA/2J and C57BL/6J showed markedly different behavioural profiles, largely consistent with previous studies examining individual tests. Avoidance of aversive environments did not increase with repeated testing. In CD-1 mice, the anxiolytics diazepam and alprazolam (4 and 2 mg/kg, respectively) increased the approach towards the EPM open arms. Alprazolam also had sedative effects, whereas the anxiogenic pentylenetetrazole had no effects.
conclusionsThese findings suggest that the triple test is sensitive to genetic/pharmacological influences on anxiety and locomotion and that, by providing quasi-simultaneous measures from three different apparatuses, it may represent an alternative to the use of test batteries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.