ReviewAmino acids2012
Manganese superoxide dismutase: beyond life and death.
Review in Amino acids, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 118 citations in OpenAlex.
- Effect of Zinc Hydroxychloride and Copper Hydroxychloride in Compound Feed on Rearing Results and Carcass Characteristics of Broiler Chickens.Animals : an open access journal from MDPI · 2026Article
- Molecular mechanisms of traditional Chinese medicine in skin aging: a narrative review.Frontiers in pharmacology · 2026Review
- Elemental comparative analysis of 18 elements reveal distinct patterns in benign and malignant thyroid tissues.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Manganese Intoxication Induced by Total Parenteral Nutrition in the Intensive Care Unit: A Case Report.Diagnostics (Basel, Switzerland) · 2025Article
- It Is All about Probiotics to Control Cervical Cancer.Probiotics and antimicrobial proteins · 2024Review
- Consequences of Disturbing Manganese Homeostasis.International journal of molecular sciences · 2023Review
- Polystyrene Microplastics Induce Oxidative Stress in Mouse Hepatocytes in Relation to Their Size.International journal of molecular sciences · 2023Article
- Protective Actions of α-Tocopherol on Cell Membrane Lipids of Paraquat-Stressed Human Astrocytes Using Microarray Technology, MALDI-MS and Lipidomic Analysis.Antioxidants (Basel, Switzerland) · 2022Article
- Differential association of antioxidative defense genes with white matter integrity in youth bipolar disorder.Translational psychiatry · 2022Article
- Antioxidants in brain tumors: current therapeutic significance and future prospects.Molecular cancer · 2022Review
- The structure-function relationships and physiological roles of MnSOD mutants.Bioscience reports · 2022Review
- Analysis of Mitochondrial Function in Cell Membranes as Indicator of Tissue Vulnerability to Drugs in Humans.Biomedicines · 2022Article
- Antioxidative Defense Genes and Brain Structure in Youth Bipolar Disorder.The international journal of neuropsychopharmacology · 2022Article
- The impact of dietary calcium and phosphorus on mitochondrial-linked gene expression in five tissues of laying hens.PloS one · 2022Article
- The "Biological Weapons" ofFrontiers in cellular and infection microbiology · 2021Review
- Isolinderalactone Induces Cell Death via Mitochondrial Superoxide- and STAT3-Mediated Pathways in Human Ovarian Cancer Cells.International journal of molecular sciences · 2020Article
- Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease.Antioxidants (Basel, Switzerland) · 2020Review
- Characterisation of recombinant thermostable manganese-superoxide dismutase (NeMnSOD) from Nerium oleander.Molecular biology reports · 2020Article
- Manganese Superoxide Dismutase Dysfunction and the Pathogenesis of Kidney Disease.Frontiers in physiology · 2020Review
- Sirtuin3 Protected Against Neuronal Damage and Cycled into Nucleus in Status Epilepticus Model.Molecular neurobiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Manganese superoxide dismutase (MnSOD) is a nuclear-encoded antioxidant enzyme that localizes to the mitochondria. Expression of MnSOD is essential for the survival of aerobic life. Transgenic mice expressing a luciferase reporter gene under the control of the human MnSOD promoter demonstrate that the level of MnSOD is reduced prior to the formation of cancer. Overexpression of MnSOD in transgenic mice reduces the incidences and multiplicity of papillomas in a DMBA/TPA skin carcinogenesis model. However, MnSOD deficiency does not lead to enhanced tumorigenicity of skin tissue similarly treated because MnSOD can modulate both the p53-mediated apoptosis and AP-1-mediated cell proliferation pathways. Apoptosis is associated with an increase in mitochondrial levels of p53 suggesting a link between MnSOD deficiency and mitochondrial-mediated apoptosis. Activation of p53 is preventable by application of a SOD mimetic (MnTE-2-PyP(5+)). Thus, p53 translocation to mitochondria and subsequent inactivation of MnSOD explain the observed mitochondrial dysfunction that leads to transcription-dependent mechanisms of p53-induced apoptosis. Administration of MnTE-2-PyP(5+) following apoptosis but prior to proliferation leads to suppression of protein carbonyls and reduces the activity of AP-1 and the level of the proliferating cellular nuclear antigen, without reducing the activity of p53 or DNA fragmentation following TPA treatment. Remarkably, the incidence and multiplicity of skin tumors are drastically reduced in mice that receive MnTE-2-PyP(5+) prior to cell proliferation. The results demonstrate the role of MnSOD beyond its essential role for survival and suggest a novel strategy for an antioxidant approach to cancer intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.