ArticlePloS one2010
The tegument of the human parasitic worm Schistosoma mansoni as an excretory organ: the surface aquaporin SmAQP is a lactate transporter.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 97 citations in OpenAlex.
- Generation of Immune Modulating Small Metabolites-Metabokines-By Adult Schistosomes.Pathogens (Basel, Switzerland) · 2025Article
- Expression, Characterization and Selective Chemical Inhibition of EssentialInternational journal of molecular sciences · 2025Article
- The riboflavin (vitamin B2) transporter protein (SmaRT) of the human intravascular parasitic trematode Schistosoma mansoni.Heliyon · 2024Article
- Human growth factor-mediated signalling through lipid rafts regulates stem cell proliferation, development and survival ofOpen biology · 2024Article
- A novel, non-neuronal acetylcholinesterase of schistosome parasites is essential for definitive host infection.Frontiers in immunology · 2023Article
- A self-purifying microfluidic system for identifying drugs acting against adult schistosomes.Royal Society open science · 2022Article
- Oncolytic Myxoma virus infects and damages the tegument of the human parasitic flatworm Schistosoma mansoni.Experimental parasitology · 2022Article
- Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis.Plant physiology · 2021Article
- Reduction of autofluorescence in whole adult worms of Schistosoma japonicum for immunofluorescence assay.Parasites & vectors · 2021Article
- Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function.International journal for parasitology · 2021Article
- Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious Diseases.Frontiers in genetics · 2021Review
- Transcriptomic Features of Echinococcus granulosus Protoscolex during the Encystation Process.The Korean journal of parasitology · 2020Article
- Tissue- and sex-specific lipidomic analysis of Schistosoma mansoni using high-resolution atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging.PLoS neglected tropical diseases · 2020Article
- A Review of Nanotechnology for Targeted Anti-schistosomal Therapy.Frontiers in bioengineering and biotechnology · 2020Review
- Vitamin B6 Acquisition and Metabolism inFrontiers in immunology · 2020Article
- Aquaporin 1 is located on the intestinal basolateral membrane in Toxocara canis and might play a role in drug uptake.Parasites & vectors · 2019Article
- Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA.Communications biology · 2019Article
- The Essential Ectoenzyme SmNPP5 from the Human Intravascular Parasite Schistosoma mansoni is an ADPase and a Potent Inhibitor of Platelet Aggregation.Thrombosis and haemostasis · 2018Article
- Infection by the Helminth ParasiteMolecular & cellular proteomics : MCP · 2018Article
- The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Adult schistosomes are intravascular parasites that metabolize imported glucose largely via glycolysis. How the parasites get rid of the large amounts of lactic acid this generates is unknown at the molecular level. Here, we report that worms whose aquaporin gene (SmAQP) has been suppressed using RNAi fail to rapidly acidify their culture medium and excrete less lactate compared to controls. Functional expression of SmAQP in Xenopus oocytes demonstrates that this protein can transport lactate following Michaelis-Menten kinetics with low apparent affinity (Km = 41+/-5. 8 mM) and with a low energy of activation (E(a) = 7.18+/-0.7 kcal/mol). Phloretin, a known inhibitor of lactate release from schistosomes, also inhibits lactate movement in SmAQP-expressing oocytes. In keeping with the substrate promiscuity of other aquaporins, SmAQP is shown here to be also capable of transporting water, mannitol, fructose and alanine but not glucose. Using immunofluorescent and immuno-EM, we confirm that SmAQP is localized in the tegument of adult worms. These findings extend the proposed functions of the schistosome tegument beyond its known capacity as an organ of nutrient uptake to include a role in metabolic waste excretion.
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