ArticleMolecular medicine (Cambridge, Mass.)
PPAR signaling pathway and cancer-related proteins are involved in celiac disease-associated tissue damage.
Article in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
- Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease.Nature immunology · 2024Trial
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- Low ACADM expression predicts poor prognosis and suppressive tumor microenvironment in clear cell renal cell carcinoma.Scientific reports · 2024Article
- Validation of the interaction between PRDX4 and TXNDC5 in gastric cancer and the significance of theTranslational cancer research · 2024Article
- Peroxiredoxins and Hypoxia-Inducible Factor-1α in Duodenal Tissue: Emerging Factors in the Pathophysiology of Pediatric Celiac Disease Patients.Current issues in molecular biology · 2023Article
- Intestinal gluconeogenesis is downregulated in pediatric patients with celiac disease.BMC medicine · 2022Article
- Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation.Acta pharmaceutica Sinica. B · 2022Article
- Transcriptome-wide analysis reveals gluten-induced suppression of small intestine development in young chickens.Journal of animal science and technology · 2022Article
- The lipid-lowering drug fenofibrate combined with si-HOTAIR can effectively inhibit the proliferation of gliomas.BMC cancer · 2021Article
- Molecular docking and machine learning analysis of Abemaciclib in colon cancer.BMC molecular and cell biology · 2020Article
- Evaluation of expression of common genes in the intestine and peripheral blood mononuclear cells (PBMC) associated with celiac disease.Gastroenterology and hepatology from bed to bench · 2020Article
- Effects ofFrontiers in immunology · 2020Article
- Comparison of cytokine and gene activities in tissue and blood samples of patients with celiac disease.Gastroenterology and hepatology from bed to bench · 2019Article
- The critical role of dysregulation of antioxidant activity and carbohydrate metabolism in celiac disease.Gastroenterology and hepatology from bed to bench · 2019Article
- Celiac disease biomarkers identified by transcriptome analysis of small intestinal biopsies.Cellular and molecular life sciences : CMLS · 2018Article
- Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas.Neuroscience bulletin · 2018Review
- SUMOylation regulates p27Kip1 stability and localization in response to TGFβ.Journal of molecular cell biology · 2016Article
- Article
- Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy.Mediators of inflammation · 2015Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Celiac disease (CD) is an immune-mediated disorder triggered by the ingestion of wheat gliadin and related proteins in genetically predisposed individuals. To find a proteomic CD diagnostic signature and to gain a better understanding of pathogenetic mechanisms associated with CD, we analyzed the intestinal mucosa proteome alterations using two dimensional difference gel electrophoresis (2D-DIGE) coupled with matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF ms) of CD patients with varying degrees of histological abnormalities defined by Marsh criteria and controls. Our results clearly evidenced the presence of two groups of patients: Group A, including controls and Marsh 0-I CD patients; and Group B, consisting of CD subjects with grade II-III Oberhuber-Marsh classification. Differentially expressed proteins were involved mainly in lipid, protein and sugar metabolism. Interestingly, in Group B, several downregulated proteins (FABP1, FABP2, APOC3, HMGCS2, ACADM and PEPCK) were implicated directly in the peroxisome proliferator-activated receptor (PPAR) signaling pathway. Moreover, Group B patients presented a deregulation of some proteins involved in apoptosis/survival pathways: phosphatidylethanolamine-binding protein 1 (PEBP1), Ras-related nuclear protein (Ran) and peroxiredoxin 4 (PRDX4). PEBP1 downregulation and RAN and PRDX4 upregulation were associated with more severe tissue damage. Likewise, IgMs were found strongly upregulated in Group B. In conclusion, our results indicate that a downregulation of proteins involved in PPAR signaling and the modulation of several cancer-related proteins are associated with the highest CD histological score according to Oberhuber-Marsh classification.
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