SynthesisBulletin of the World Health Organization2009
Artemisinin derivatives versus quinine for cerebral malaria in African children: a systematic review.
Synthesis in Bulletin of the World Health Organization, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Pooled it
- Artemether for severe malaria.The Cochrane database of systematic reviews · 2019Pooled it
- Artemether for severe malaria.The Cochrane database of systematic reviews · 2014Pooled it
- Artesunate versus quinine for treating severe malaria.The Cochrane database of systematic reviews · 2012Pooled it
- Efficacy of a novel sublingual spray formulation of artemether in African children with Plasmodium falciparum malaria.Antimicrobial agents and chemotherapy · 2015Trial
- Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial.Malaria journal · 2015Trial
- Pharmacokinetics of a novel sublingual spray formulation of the antimalarial drug artemether in healthy adults.Antimicrobial agents and chemotherapy · 2015Trial
- Pharmacokinetics of a novel sublingual spray formulation of the antimalarial drug artemether in African children with malaria.Antimicrobial agents and chemotherapy · 2015Trial
- Inhaled nitric oxide for the adjunctive therapy of severe malaria: protocol for a randomized controlled trial.Trials · 2011Trial
- Review
- Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria.PLoS pathogens · 2025Article
- Nitric oxide: Clinical applications in critically ill patients.Nitric oxide : biology and chemistry · 2022Review
- Parenteral artemisinins are associated with reduced mortality and neurologic deficits and improved long-term behavioral outcomes in children with severe malaria.BMC medicine · 2021Observational
- Treatment of Experimental Cerebral Malaria by Slow Release of Artemisone From Injectable Pasty Formulation.Frontiers in pharmacology · 2020Article
- Rocaglates as dual-targeting agents for experimental cerebral malaria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Exploring neurodevelopmental outcome measures used in children with cerebral malaria: the perspectives of caregivers and health workers in Malawi.BMC pediatrics · 2017Article
- Performance of point-of-care diagnostics for glucose, lactate, and hemoglobin in the management of severe malaria in a resource-constrained hospital in Uganda.The American journal of tropical medicine and hygiene · 2014Article
- Quinine localizes to a non-acidic compartment within the food vacuole of the malaria parasite Plasmodium falciparum.Malaria journal · 2012Article
- The Impact of HIV Coinfection on Cerebral Malaria Pathogenesis.Journal of neuroparasitology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo summarize the existing evidence on the efficacy of artemether and arteether, two artemisinin derivatives, versus quinine for treating cerebral malaria in children.
methodsWe searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and the http://clinicaltrials.gov web site. We also checked the reference lists of existing systematic reviews and of all trials identified by the above methods. We searched exclusively for randomized controlled trials (RCTs) comparing artemether/arteether with quinine for treating cerebral malaria in children. Two independent reviewers assessed study eligibility and trial quality and extracted the data.
findingsNine RCTs were included in the analysis, and all were from Africa. Five had adequate allocation concealment. Seven trials compared artemether with quinine (1220 children), and two compared arteether with quinine (194 children). No statistically significant difference was found between artemisinin derivatives and quinine in preventing mortality (relative risk, RR: 0.91; 95% confidence interval, CI: 0.73-1.14; I(2): 0%). The quality of the evidence, as assessed by the Grade evidence profile, was moderate. The only serious adverse event was seen in a patient in the quinine group who developed fatal black water fever.
conclusionArtemisinin derivatives are not inferior to quinine in preventing death in children with cerebral malaria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.