ArticlePloS one2010
Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 62 citations in OpenAlex.
- Intertwined and unequal causality of type 1 diabetes and autoimmune thyroid disease: Insights from Mendelian randomization.Medicine · 2025Article
- Genetic association betweenFrontiers in genetics · 2025Article
- STAT4 gene polymorphisms in human diseases.Frontiers in immunology · 2024Review
- Article
- Frequency distribution of cytokine and associated transcription factor single nucleotide polymorphisms in Zimbabweans: Impact on schistosome infection and cytokine levels.PLoS neglected tropical diseases · 2022Article
- Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients.Journal, genetic engineering & biotechnology · 2021Article
- Protein kinase 2 (CK2) controls CD4Mucosal immunology · 2020Article
- Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn's disease.World journal of gastroenterology · 2020Review
- GenePANDA-a novel network-based gene prioritizing tool for complex diseases.Scientific reports · 2017Article
- Beryllium-induced lung disease exhibits expression profiles similar to sarcoidosis.The European respiratory journal · 2016Article
- Integrating Immunologic Signaling Networks: The JAK/STAT Pathway in Colitis and Colitis-Associated Cancer.Vaccines · 2016Review
- Host-microbiome interaction in Crohn's disease: A familiar or familial issue?World journal of gastrointestinal pathophysiology · 2015Review
- Altered STAT4 Isoform Expression in Patients with Inflammatory Bowel Disease.Inflammatory bowel diseases · 2015Article
- STAT4 genetic polymorphisms association with spontaneous clearance of hepatitis B virus infection.Immunologic research · 2015Article
- Association between STAT4 gene polymorphisms and autoimmune thyroid diseases in a Chinese population.International journal of molecular sciences · 2014Article
- Association of STAT4 gene rs7574865G > T polymorphism with ulcerative colitis risk: evidence from 1532 cases and 3786 controls.Archives of medical science : AMS · 2014Review
- Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics.Gastroenterology · 2013Review
- Association between polymorphisms in osteopontin gene (SPP1) and first episode calcium oxalate urolithiasis.Urolithiasis · 2013Article
- How does genotype influence disease phenotype in inflammatory bowel disease?Inflammatory bowel diseases · 2013Review
- Polymorphisms ofBiomedical reports · 2013Article
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Authors and funding
17 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 variants on the susceptibility and phenotype of inflammatory bowel diseases (IBD) in a large patient and control cohort. METHODOLOGY/PRINCIPAL
findingsGenomic DNA from 2704 individuals of Caucasian origin including 857 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1383 healthy, unrelated controls was analyzed for seven SNPs in the STAT4 gene (rs11889341, rs7574865, rs7568275, rs8179673, rs10181656, rs7582694, rs10174238). In addition, a detailed genotype-phenotype analysis was performed. Our analysis revealed an association of the STAT4 SNP rs7574865 with overall decreased susceptibility to CD (p = 0.047, OR 0.86 [95% CI 0.74-0.99]). However, compared to CD patients carrying the wild type genotype, the STAT4 SNP rs7574865 was significantly associated with early CD onset (p = 0.021) and colonic CD (p = 0.008; OR = 4.60, 95% CI 1.63-12.96). For two other STAT4 variants, there was a trend towards protection against CD susceptibility (rs7568275, p = 0.058, OR 0.86 [95% CI 0.74-1.00]; rs10174238, p = 0.057, OR 0.86 [95% CI 0.75-1.00]). In contrast, we did not observe any association with UC susceptibility. Evidence for weak gene-gene interaction of STAT4 with the IL23R SNP rs11209026 was lost after Bonferroni correction. CONCLUSIONS/SIGNIFICANCE: Our results identified the STAT4 SNP rs7574865 as a disease-modifying gene variant in colonic CD. However, in contrast to SLE and RA, the effect of rs7574865 on CD susceptibility is only weak.
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