ArticleThe Journal of cell biology1991
Insulin-like growth factors I and II are produced in the metanephros and are required for growth and development in vitro.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 128 citations in OpenAlex.
- Review
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- Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis.International journal of molecular sciences · 2016Review
- Transcriptional dysregulation in the ureteric bud causes multicystic dysplastic kidney by branching morphogenesis defect.The Journal of urology · 2015Article
- Article
- Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development.Journal of the American Society of Nephrology : JASN · 2013Article
- Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice.Development (Cambridge, England) · 2012Article
- Receptor tyrosine kinases in kidney development.Journal of signal transduction · 2011Article
- Renal differentiation of amniotic fluid stem cells.Cell proliferation · 2007Article
- Critical and distinct roles for key RET tyrosine docking sites in renal development.Genes & development · 2006Article
- Insulin-like growth factor binding protein-2 modulates podocyte mitogenesis.Pediatric nephrology (Berlin, Germany) · 2003Article
- Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome.The American journal of pathology · 2000Article
- Mannose 6-phosphate/insulin-like growth factor 2 receptor, a bona fide tumor suppressor gene or just a promising candidate?Journal of mammary gland biology and neoplasia · 2000Review
- WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts.Oncogene · 1999Article
- Evaluation of metanephric maturation in a human fetal kidney explant model.In vitro cellular & developmental biology. Animal · 1998Article
- An in vitro tubulogenesis system using cell lines derived from the embryonic kidney shows dependence on multiple soluble growth factors.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis.The Journal of clinical investigation · 1997Article
- Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7).Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- IGF-II dependent autocrine growth in cell lines derived from renal tumours of childhood.Clinical molecular pathology · 1995Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The role(s) of one family of polypeptide growth factors in a developing organ system was examined. Renal anlagen (metanephroi) were surgically removed from 13-d-old rat embryos and grown in organ culture for up to 6 d. Over this period of time when placed in serum-free defined media, the metanephroi increased in size and morphologic complexity. Messenger RNAs for both insulin-like growth factors (IGFs), IGF I and IGF II, were present in the metanephroi. Immunoreactive IGF I and IGF II were produced by the renal anlagen and released into culture media. Levels were relatively constant during the 6 d in culture and averaged 3.5 X 10(-9) M IGF I and 8.3 X 10(-9) M IGF II in media removed from metanephroi after contact for 24 h. IGF binding protein activity was not detected in culture media. Growth and development of metanephroi in vitro was prevented by the addition of anti-IGF I or anti-IGF II antibodies to organ cultures. IGF II produced by metanephroi was active in an IGF II biological assay system and addition of anti-IGF II receptor antibodies to organ cultures prevented growth and development, consistent with the action of IGF II in metanephroi being mediated via the IGF II receptor. The data demonstrate production of both IGF I and IGF II by developing rat metanephroi in organ culture. Each of these peptides is necessary for growth and development of the renal anlage to take place in vitro. Our findings suggest that both IGF I and IGF II are produced within the developing metanephros in vivo and promote renal organogenesis.
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