ArticleJournal of applied genetics2010
Genetics of fat tissue accumulation in pigs: a comparative approach.
Article in Journal of applied genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- A meta-analysis of genetic and phenotypic diversity of European local pig breeds reveals genomic regions associated with breed differentiation for production traits.Genetics, selection, evolution : GSE · 2023Pooled it
- Heat Stress and Betaine Affect Lipolysis in Pig Adipose Tissue Explants.Animals : an open access journal from MDPI · 2025Article
- Identification of Signatures of Positive Selection That Have Shaped the Genomic Landscape of South African Pig Populations.Animals : an open access journal from MDPI · 2024Article
- The Effect ofAnimals : an open access journal from MDPI · 2023Article
- Altered hair root gene expression profiles highlight calcium signaling and lipid metabolism pathways to be associated with curly hair initiation and maintenance in Mangalitza pigs.Frontiers in genetics · 2023Article
- Integrated Analysis of Long Non-Coding RNA and mRNA to Reveal Putative Candidate Genes Associated with Backfat Quality in Beijing Black Pig.Foods (Basel, Switzerland) · 2022Article
- Genes Related to Fat Metabolism in Pigs and Intramuscular Fat Content of Pork: A Focus on Nutrigenetics and Nutrigenomics.Animals : an open access journal from MDPI · 2022Review
- ssc-miR-451 Regulates Porcine Primary Adipocyte Differentiation by Targeting ACACA.Animals : an open access journal from MDPI · 2020Article
- Identification of Molecular Mechanisms Related to Pig Fatness at the Transcriptome and miRNAome Levels.Genes · 2020Article
- Lipid Deposition and Metabolism in Local and Modern Pig Breeds: A Review.Animals : an open access journal from MDPI · 2020Review
- Expression of lipid metabolism genes provides new insights into intramuscular fat deposition in Laiwu pigs.Asian-Australasian journal of animal sciences · 2020Article
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- Analysis of allele-specific expression of seven candidate genes involved in lipid metabolism in pig skeletal muscle and fat tissues reveals allelic imbalance of ACACA, LEP, SCD, and TNF.Journal of applied genetics · 2019Article
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- Article
- Genetics of body fat mass and related traits in a pig population selected for leanness.Scientific reports · 2017Article
- Genetic Marker Discovery in Complex Traits: A Field Example on Fat Content and Composition in Pigs.International journal of molecular sciences · 2016Review
- Expression of genes involved in lipid droplet formation (BSCL2, SNAP23 and COPA) during porcine in vitro adipogenesis.Journal of applied genetics · 2016Article
- Polymorphisms of the porcine cathepsins, growth hormone-releasing hormone and leptin receptor genes and their association with meat quality traits in Ukrainian Large White breed.Molecular biology reports · 2016Article
- Pig fatness in relation to FASN and INSIG2 genes polymorphism and their transcript level.Molecular biology reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatness traits are important in pig production since they influence meat quality and fattening efficiency. On the other hand, excessive fat accumulation in humans has become a serious health problem due to worldwide spread of obesity. Since the pig is also considered as an animal model for numerous human diseases, including obesity and metabolic syndrome, comparative genomic studies may bring new insights into genetics of fatness/obesity. Input of genetic factors into phenotypic variability of these traits is rather high and the heritability coefficient (h(2)) of these traits oscillates around 0.5. Genome scanning revealed the presence of more than 500 QTLs for fatness in the pig genome. In addition to QTL studies, many candidate gene polymorphisms have been analyzed in terms of their associations with pig fatness, including genes encoding leptin (LEP) and its receptor (LEPR), insulin-like growth factor 2 (IGF-2), fatty acid-binding proteins (FABP3 and FABP4), melanocortin receptor type 4 (MC4R), and the FTO (fat mass and obesity-associated) gene. Among them, a confirmed effect on pig fatness was found for a well-known polymorphism of the IGF-2 gene. In humans the strongest association with predisposition to obesity was shown for polymorphism of the FTO gene, while in pigs such an association seems to be doubtful. The development of functional genomics has revealed a large number of genes whose expression is associated with fat accumulation and lipid metabolism, so far not studied extensively in terms of the association of their polymorphism with pig fatness. Recently, epigenomic mechanisms, mainly RNA interference, have been considered as a potential source of information on genetic input into the fat accumulation process. The rather limited progress in studies focused on the identification of gene polymorphism related with fatness traits shows that their genetic background is highly complex.
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Registered trials
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