ReviewCold Spring Harbor symposia on quantitative biology2009
Genetic structure in African populations: implications for human demographic history.
Review in Cold Spring Harbor symposia on quantitative biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.Nature communications · 2026Pooled it
- Genome admixture analysis of 1,030 Ugandan infants with neonatal sepsis and hydrocephalus demonstrates geographical stratification of population disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever.Nature microbiology · 2024Article
- High-resolution HLA allele and haplotype frequencies in several unrelated populations determined by next generation sequencing: 17th International HLA and Immunogenetics Workshop joint report.Human immunology · 2021Article
- A different view on fine-scale population structure in Western African populations.Human genetics · 2020Article
- Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness.PloS one · 2020Article
- Cardiovascular Disease Epidemiology in Portuguese-Speaking Countries: data from the Global Burden of Disease, 1990 to 2016.Arquivos brasileiros de cardiologia · 2018Article
- A Genomic and Protein-Protein Interaction Analyses of Nonsyndromic Hearing Impairment in Cameroon Using Targeted Genomic Enrichment and Massively Parallel Sequencing.Omics : a journal of integrative biology · 2017Article
- Common genetic variants and subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA).Atherosclerosis · 2016Article
- The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity.Current opinion in endocrinology, diabetes, and obesity · 2016Review
- A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches.Human genetics · 2015Review
- Genetic mutations in African patients with atrial fibrillation: Rationale and design of the Study of Genetics of Atrial Fibrillation in an African Population (SIGNAL).American heart journal · 2015Article
- Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers.BMC medical genomics · 2014Article
- Frequency of APOE, MTHFR and ACE polymorphisms in the Zambian population.BMC research notes · 2014Article
- Recent human adaptation: genomic approaches, interpretation and insights.Nature reviews. Genetics · 2013Review
- Omics technologies and the study of human ageing.Nature reviews. Genetics · 2013Review
- Article
- Personal receptor repertoires: olfaction as a model.BMC genomics · 2012Article
- Analysis for genotyping Duffy blood group in inhabitants of Sudan, the fourth cataract of the Nile.Malaria journal · 2012Article
- The Genetic Diversity and Structure of Linkage Disequilibrium of the MTHFR Gene in Populations of Northern Eurasia.Acta naturae · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The continent of Africa is the source of all anatomically modern humans that dispersed across the planet during the past 100,000 years. As such, African populations are characterized by high genetic diversity and low levels of linkage disequilibrium (LD) among loci, as compared to populations from other continents. African populations also possess a number of genetic adaptations that have evolved in response to the diverse climates, diets, geographic environments, and infectious agents that characterize the African continent. Recently, Tishkoff et al. (2009) performed a genome-wide analysis of substructure based on DNA from 2432 Africans from 121 geographically diverse populations. The authors analyzed patterns of variation at 1327 nuclear microsatellite and insertion/deletion markers and identified 14 ancestral population clusters that correlate well with self-described ethnicity and shared cultural or linguistic properties. The results suggest that African populations may have maintained a large and subdivided population structure throughout much of their evolutionary history. In this chapter, we synthesize recent work documenting evidence of African population structure and discuss the implications for inferences about evolutionary history in both African populations and anatomically modern humans as a whole.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.