ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2010
Gender specificity of altered human immune cytokine profiles in aging.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
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- Integrative approaches to healthy aging in postmenopausal women: the synergistic benefits of exercise combined with functional foods and dietary supplements.Frontiers in endocrinology · 2026Review
- Salt sensitivity of blood pressure: mechanisms and sex-specific differences.Nature reviews. Cardiology · 2025Review
- Sex Differences in Immune Responses to Infectious Diseases: The Role of Genetics, Hormones, and Aging.Diseases (Basel, Switzerland) · 2025Review
- Aging Is Associated With Decreased Lactobacillus and Increased Cervicovaginal Inflammation in Canadian Women.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Article
- A fundamental relationship between TCR diversity, repertoire size and systemic clonal expansion: insights from 30,000 TCRFrontiers in immunology · 2025Article
- Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations.Frontiers in immunology · 2025Review
- Senescent T Cells: The Silent Culprit in Acute Myeloid Leukemia Progression?International journal of molecular sciences · 2024Review
- Considering the role of estradiol in the psychoneuroimmunology of perimenopausal depression.Brain, behavior, & immunity - health · 2024Article
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- Epigenomic variability is associated with age-specific naïve CD4 T cell response to activation in infants and adolescents.Immunology and cell biology · 2023Article
- COVID-19 Clinical Features and Outcomes in Elderly Patients during Six Pandemic Waves.Journal of clinical medicine · 2022Article
- A tale of two systems: Lessons learned from female mid-life aging with implications for Alzheimer's prevention & treatment.Ageing research reviews · 2022Review
- Sex bias in lymphocytes: Implications for autoimmune diseases.Frontiers in immunology · 2022Review
- Proinflammatory profile in the skin of Parkinson's disease patients with and without pain.PloS one · 2022Article
- Roadmap for Sex-Responsive Influenza and COVID-19 Vaccine Research in Older Adults.Frontiers in aging · 2022Review
- Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life.Cytokine · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Cytokine generation by T cells and monocytes was determined for 50 subjects aged 65 yr or older and concurrently studied young subjects individually matched to each old subject for sex, race, and national origin. Highly significant differences between cytokine levels of old and young subjects all were gender specific. For T cells stimulated with anti-CD3 plus anti-CD28 antibodies, mean ratios of IFN-gamma generation for healthy old to young subjects were 0.22 for men (P<0.001; n=15) and 3.35 for women (P<0.001; n=13), and those of IL-17 were 0.30 for men (P<0.001) and no difference for women. CD8 T cells were the source of high IFN-gamma in healthy old women. For old men with an inflammatory or immune disease (n=10), mean old to young ratios of T-cell-generated IFN-gamma and IL-17 increased with disease severity up to 5.78 and 2.97 (both P<0.01), respectively, without changes for old women with similar diseases (n=12). For differentiated LPS-stimulated monocytes, old to young ratios of TNF-alpha and IL-6 generation were high only in women with immune or inflammatory disease (2.38, P<0.05 and 1.62, P<0.01, respectively), whereas ratios of IFN-gamma-evoked IP-10 chemokine were low in all groups. Alterations in immune cytokine profiles with aging show significant gender specificity.
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