ArticleMolecular biology and evolution2010
Can a sex-biased human demography account for the reduced effective population size of chromosome X in non-Africans?
Article in Molecular biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- Identifying X-chromosome variants associated with age-related macular degeneration.Human molecular genetics · 2024Article
- Genomic and demographic processes differentially influence genetic variation across the human X chromosome.PloS one · 2023Article
- Changes in life history and population size can explain the relative neutral diversity levels on X and autosomes in extant human populations.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The inference of sex-biased human demography from whole-genome data.PLoS genetics · 2019Article
- Evaluating genomic signatures of "the large X-effect" during complex speciation.Molecular ecology · 2018Review
- Genetic Diversity on the Sex Chromosomes.Genome biology and evolution · 2018Review
- Contrasting Patterns of Genomic Diversity Reveal Accelerated Genetic Drift but Reduced Directional Selection on X-Chromosome in Wild and Domestic Sheep Species.Genome biology and evolution · 2018Article
- Explosive genetic evidence for explosive human population growth.Current opinion in genetics & development · 2016Review
- Article
- Genetic Diversity on the Human X Chromosome Does Not Support a Strict Pseudoautosomal Boundary.Genetics · 2016Article
- Strong Selective Sweeps on the X Chromosome in the Human-Chimpanzee Ancestor Explain Its Low Divergence.PLoS genetics · 2015Article
- Article
- Contrasting X-linked and autosomal diversity across 14 human populations.American journal of human genetics · 2014Article
- Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases.PloS one · 2014Article
- Purifying selection causes widespread distortions of genealogical structure on the human X chromosome.Genetics · 2013Article
- Ancestral polymorphisms and sex-biased migration shaped the demographic history of brown bears and polar bears.PloS one · 2013Article
- Extensive X-linked adaptive evolution in central chimpanzees.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing.Nature genetics · 2011Article
- The Nubian Complex of Dhofar, Oman: an African middle stone age industry in Southern Arabia.PloS one · 2011Article
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Abstract
Sex-biased demographic events can result in asymmetries in female and male effective population size that can lead to different patterns of genetic variation on chromosome X than are expected based on the patterns on the autosomes. Previous studies point to a period around the time of the dispersal of anatomically modern humans out of Africa when chromosome X experienced a significant reduction in effective population size relative to the autosomes. Here, we explore whether a sex-biased demographic history could explain these observations. We use coalescent simulations to show that a model of primarily male migration during the out-of-Africa dispersal can produce the striking patterns that are observed when comparing patterns of genetic variation on the autosomes and chromosome X. The model involves a history in which after the founder population of non-Africans lost much of its genetic diversity, subsequent mostly male gene flow from an African source brought new diversity into the population. We also explore two additional models, one of sex-biased generation time and one of a substructured population during the dispersal out of Africa with primarily female migration among demes. These latter models cannot account for the magnitude of the observed reduction in chromosome X effective population size, although it is plausible that they played a more minor role in producing the striking chromosome X/autosome patterns.
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