ArticleThe Journal of biological chemistry2010
CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP).
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- IL-6 selectively suppresses cDC1 specification via C/EBPβ.The Journal of experimental medicine · 2023Article
- Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins.Nucleic acids research · 2023Article
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- FOXO transcription factors differ in their dynamics and intra/intermolecular interactions.Current research in structural biology · 2022Article
- Dynamic Autoinhibition of the HMGB1 Protein via Electrostatic Fuzzy Interactions of Intrinsically Disordered Regions.Journal of molecular biology · 2021Article
- p300 Mediates Muscle Wasting in Lewis Lung Carcinoma.Cancer research · 2019Article
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- The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse.Scientific reports · 2018Article
- Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets.Cancer research · 2018Article
- JunD/AP-1 Antagonizes the Induction of DAPK1 To Promote the Survival of v-Src-Transformed Cells.Journal of virology · 2017Article
- CBP-CITED4 is required for luteinizing hormone-triggered target gene expression during ovulation.Molecular human reproduction · 2014Article
- Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300.Acta crystallographica. Section D, Biological crystallography · 2014Article
- H2A.Z-dependent crosstalk between enhancer and promoter regulates cyclin D1 expression.Oncogene · 2013Article
- Shaping the murine macrophage phenotype: IL-4 and cyclic AMP synergistically activate the arginase I promoter.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ.Molecular and cellular biology · 2013Article
- Lymphoid to myeloid cell trans-differentiation is determined by C/EBPβ structure and post-translational modifications.PloS one · 2013Article
- p38β MAPK upregulates atrogin1/MAFbx by specific phosphorylation of C/EBPβ.Skeletal muscle · 2012Article
- Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.Nature medicine · 2012Article
- Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB.Nature · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Signaling through Ras GTPases controls the activity of many transcription factors including CCAAT/enhancer-binding protein (C/EBPbeta), which regulates oncogenic H-Ras(V12)-induced senescence and growth arrest. Here we report that C/EBPbeta (LAP) DNA binding is inhibited by N-terminal sequences and derepressed by oncogenic Ras signaling. Sequence and mutational analyses showed that auto-repression involves two LXXLF (phiXXphiphi)-like motifs (LX1 and LX2) and a third element, auto-inhibitory domain (AID), located within conserved region CR5. LX1 is a critical component of the transactivation domain and has been shown to mediate C/EBPbeta binding to the TAZ2 region of p300/CREB-binding protein coactivators. C/EBPbeta auto-repression also involves a C-terminal regulatory domain (CRD) adjacent to the leucine zipper. CRD contains a third phiXXphiphi motif (LX3) and a short sequence, KQL, which has similarity to a region in the protein-binding site of TAZ2. The C/EBPbeta N- and C-terminal domains physically associate in a manner that requires the basic region and CRD. We propose a model in which the regulatory sequences form a hydrophobic core that reciprocally inhibits DNA binding and transactivation. We also suggest a mechanism for C/EBPbeta derepression involving several recently identified modifications within AID and CRD. Finally, we show that association of activated C/EBPbeta with p300/CREB-binding protein requires the LX2 and AID auto-inhibitory elements. Thus, the N-terminal regulatory elements have dual roles in auto-inhibition and coactivator binding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.