ArticleBiomaterials2010
The functional behavior of a macrophage/fibroblast co-culture model derived from normal and diabetic mice with a marine gelatin-oxidized alginate hydrogel.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Advancement in Sodium Alginate-Based Drug Delivery Systems: Applications and Future Prospects.AAPS PharmSciTech · 2026Review
- Comparative Late Effects of Hemostatic Biomaterials on Wound Healing at 14 and 30 Days: An In Vivo Animal Study.Journal of functional biomaterials · 2026Article
- Modulation of Chemokine Activity for Enhanced Angiogenesis and Tissue Regeneration in Chronic Wounds.International journal of molecular sciences · 2026Review
- Hierarchical double-layer microneedles accomplish multicenter skin regeneration in diabetic full-thickness wounds.Journal of advanced research · 2024Article
- Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies.ACS omega · 2024Review
- Recent Advances in Alginate-Based Hydrogels for Cell Transplantation Applications.Pharmaceutics · 2024Review
- Effect of Gelatin-Based Hemostats on Fibroblasts and Relevant Growth Factors in Wound Healing.Gels (Basel, Switzerland) · 2023Article
- Effects of 3-HAA on HCC by Regulating the Heterogeneous Macrophages-A scRNA-Seq Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Immunomodulatory biomaterials on chemokine signaling in wound healing.Frontiers in pharmacology · 2023Review
- Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing.Bioengineering & translational medicine · 2022Article
- Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds.BioMed research international · 2022Review
- GAS6/Axl Signaling Modulates Blood-Brain Barrier Function Following Intravenous Thrombolysis in Acute Ischemic Stroke.Frontiers in immunology · 2021Article
- Enhancing responsiveness of human jejunal enteroids to host and microbial stimuli.The Journal of physiology · 2020Article
- Anticancer Therapeutic Alginate-Based Tissue Sealants for Lung Repair.ACS applied materials & interfaces · 2017Article
- Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges.NPJ Regenerative medicine · 2017Review
- Mononuclear-macrophages but not neutrophils act as major infiltrating anti-leptospiral phagocytes during leptospirosis.PloS one · 2017Article
- Biocompatibility Assessment of a New Biodegradable Vascular Graft via In Vitro Co-culture Approaches and In Vivo Model.Annals of biomedical engineering · 2016Article
- Towards an in vitro model mimicking the foreign body response: tailoring the surface properties of biomaterials to modulate extracellular matrix.Scientific reports · 2014Article
- 3-D culture of human umbilical vein endothelial cells with reversible thermosensitive hydroxybutyl chitosan hydrogel.Journal of materials science. Materials in medicine · 2013Article
- Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers.Tissue engineering. Part A · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tissues/cells-mediated biodegradable material degradation is epitomized by the constantly changing tissues/cell-implant interface, implicating the constant adaptation of the tissues/cells. Macrophages and fibroblasts are multi-functional cells highly involved in the interactions; the two cell types modulates the behaviors of each other, but their combinatorial functional behavior in the presence of interactive bioactive wound dressings has not been adequately examined. The activity is further complicated by the implantation of biodegradable materials, such as hydrogels commonly utilized as wound dressings, in a pathological environment and this is exemplified by the macrophages with a diabetic pathology producing an alternative cytokine profile which is implicated in wound healing delay. In this study, an in situ gelable formable/conformable hydrogel formulated from modified alginate and marine gelatin was used as a model biodegradable interactive wound dressing to elucidate the combinatorial behavior of macrophages/fibroblasts derived from both normal and diabetic hosts. Cell proliferation, migration and distribution were first characterized; this was followed by simultaneous quantitative detection of 40 inflammatory cytokines and chemokines by a protein microarray. The results showed that the macrophages/fibroblasts co-culture promoted fibroblasts proliferation and migration in the presence of the hydrogel; moreover, the expressions of inflammatory cytokines and chemokines were altered when compared with the corresponding fibroblasts or macrophages monocultures. The inflammatory cytokines patterns between the normal and diabetic hosts were considerably different.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.