ArticleAmerican journal of obstetrics and gynecology2010
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.
Article in American journal of obstetrics and gynecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel.BMC medicine · 2026Pooled it
- Genetic variation associated with preterm birth in African-American women.American journal of obstetrics and gynecology · 2016Trial
- Trial
- Phenotypes of Preterm Birth: A Retrospective Cohort Study from a Tertiary Romanian Centre as a Framework for Future Genomic and Proteomic Research.Journal of clinical medicine · 2026Article
- A systematic scoring system to optimise the testing of neurotherapeutics in models of perinatal brain injury, with an applied case study of human umbilical-cord MSC.Journal of neuroinflammation · 2025Article
- Environmental and genetic risk factors for preterm birth: interplays with stressful events during pregnancy.Pediatric research · 2025Article
- Genomic Differences between Spontaneous versus Indicated Extreme Preterm Birth.American journal of perinatology · 2025Article
- Maternal-fetal conflict and the timing of birth.Evolution, medicine, and public health · 2025Review
- Extrauterine support of pre-term lambs achieves similar transcriptomic profiling to late pre-term lamb brains.Scientific reports · 2024Article
- Human Genetic Variation in F3 and Its Impact on Tissue Factor-Dependent Disease.Seminars in thrombosis and hemostasis · 2024Review
- Recent Advances and Challenges in the Early Diagnosis and Treatment of Preterm Labor.Bioengineering (Basel, Switzerland) · 2024Review
- Systems biology approach: identification of hub genes, signaling pathways, and molecular docking of COL1A1 gene in cervical insufficiency.In silico pharmacology · 2024Article
- The Role of Genetics in Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Genetic contributions to risk of adverse pregnancy outcomes.Current cardiovascular risk reports · 2023Article
- Comprehensive Analysis of the Role of Gene Variants in Matrix Metalloproteinases and Their Tissue Inhibitors in Retinopathy of Prematurity: A Study in the Polish Population.International journal of molecular sciences · 2023Article
- Emerging role of toll-like receptors signaling and its regulators in preterm birth: a narrative review.Archives of gynecology and obstetrics · 2023Review
- Associations of VEGF Polymorphisms With Retinopathy of Prematurity.Investigative ophthalmology & visual science · 2023Article
- Genes, exposures, and interactions on preterm birth risk: an exploratory study in an Argentine population.Journal of community genetics · 2022Article
- Systematic review of preterm birth multi-omic biomarker studies.Expert reviews in molecular medicine · 2022Review
- Protein interaction networks define the genetic architecture of preterm birth.Scientific reports · 2022Article
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Authors and funding
21 authors at 10 institutions in 2 countries.
Funding
Abstract
objectiveThe purpose of this study was to determine whether maternal/fetal single nucleotide polymorphisms (SNPs) in candidate genes are associated with spontaneous preterm labor/delivery. STUDY
designA genetic association study was conducted in 223 mothers and 179 fetuses (preterm labor with intact membranes who delivered <37 weeks of gestation [preterm birth (PTB)]), and 599 mothers and 628 fetuses (normal pregnancy); 190 candidate genes and 775 SNPs were studied. Single locus/haplotype association analyses were performed; the false discovery rate was used to correct for multiple testing.
resultsThe strongest single locus associations with PTB were interleukin-6 receptor 1 (fetus; P=.000148) and tissue inhibitor of metalloproteinase 2 (mother; P=.000197), which remained significant after correction for multiple comparisons. Global haplotype analysis indicated an association between a fetal DNA variant in insulin-like growth factor F2 and maternal alpha 3 type IV collagen isoform 1 (global, P=.004 and .007, respectively).
conclusionAn SNP involved in controlling fetal inflammation (interleukin-6 receptor 1) and DNA variants in maternal genes encoding for proteins involved in extracellular matrix metabolism approximately doubled the risk of PTB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.