Evidence map›Paper›PMID 20452467›Full record

ReviewRespiratory physiology & neurobiology2010

Respiratory modulation of premotor cardiac vagal neurons in the brainstem.

Olga Dergacheva, Kathleen J Griffioen, Robert A Neff, David Mendelowitz

Abstract readReview
In one paragraph

Review in Respiratory physiology & neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Olga DergachevaDepartment of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA.
Kathleen J Griffioen
Robert A Neff
David Mendelowitz

Funding

Nicotine Modulation of Parasympathetic Cardiac NeuronsR01HL072006 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI MENDELOWITZ, DAVID · 2003 to 2017
$5.4M
NEUROPHYSIOLOGY OF PARASYMPATHETIC CARDIAC NEURONSR01HL049965 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MENDELOWITZ, DAVID · 1998 to 2014
$4.6M
MECHANISM OF CARDIORESPIRATORY RHYTHM IN NEONATESR01HL059895 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MENDELOWITZ, DAVID · 1998 to 2013
$4.1M
NEUROPHYSIOLOGY OF PARASYMPATHETIC CARDIAC NEURONSR29HL049965 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MENDELOWITZ, DAVID · 1993 to 1997
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NHLBI NIH HHS HL49965NHLBI NIH HHS HL59895NHLBI NIH HHS HL72006NHLBI NIH HHS R01 HL049965NHLBI NIH HHS R01 HL059895NHLBI NIH HHS R01 HL072006
6 · The paper itself

Abstract

The respiratory and cardiovascular systems are highly intertwined, both anatomically and physiologically. Respiratory and cardiovascular neurons are often co-localized in the same brainstem regions, and this is particularly evident in the ventral medulla which contains presympathetic neurons in the rostral ventrolateral medulla, premotor parasympathetic cardioinhibitory neurons in the nucleus ambiguus, and the ventral respiratory group, which includes the pre-Botzinger complex. Anatomical studies of respiratory and cardiovascular neurons have demonstrated that many of these neurons have projections and axon collateral processes which extend into their neighboring cardiorespiratory regions providing an anatomical substrate for cardiorespiratory interactions. As other reports in this Special Issue of Respiratory Physiology & Neurobiology focus on interactions between the respiratory network and baroreceptors, neurons in the nucleus tractus solitarius, presympathetic neurons and sympathetic activity, this report will focus on the respiratory modulation of parasympathetic activity and the neurons that generate parasympathetic activity to the heart, cardiac vagal neurons.

Indexed as

RespirationAnimalsBrain StemHeartHumansMedulla OblongataMotor NeuronsVagus Nerve

Identifiers

PMID20452467
PMCPMC2932818

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.