ArticleNeurobiology of disease2010
Interictal spikes in developing rats cause long-standing cognitive deficits.
Article in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Clinical features of benign epilepsy of childhood with centrotemporal spikes in chinese children.Medicine · 2017Trial
- Timing is everything: The effect of early-life seizures on developing neuronal circuits subserving spatial memory.Epilepsia open · 2025Review
- Modeling the Interictal Epileptic State for Therapeutic Development with Tetanus Toxin.Brain sciences · 2024Review
- Article
- Spike-induced cytoarchitectonic changes in epileptic human cortex are reduced via MAP2K inhibition.Brain communications · 2024Article
- Modulation of locomotor behaviors by location-specific epileptic spiking and seizures.Epilepsy & behavior : E&B · 2021Article
- Cannabidiol improves survival and behavioural co-morbidities of Dravet syndrome in mice.British journal of pharmacology · 2020Article
- The Role of EEG-fMRI in Studying Cognitive Network Alterations in Epilepsy.Frontiers in neurology · 2019Review
- The Impact of Interictal Discharges on Performance.Current neurology and neuroscience reports · 2018Review
- Transient Cognitive Impairment in Epilepsy.Frontiers in molecular neuroscience · 2018Article
- Why Are Children With Epileptic Encephalopathies Encephalopathic?Journal of child neurology · 2016Review
- Interictal epileptiform discharges induce hippocampal-cortical coupling in temporal lobe epilepsy.Nature medicine · 2016Article
- Effect of Seizures on the Developing Brain and Cognition.Seminars in pediatric neurology · 2016Review
- Interictal epileptiform discharge effects on neuropsychological assessment and epilepsy surgical planning.Epilepsy & behavior : E&B · 2016Review
- Neonatal and Infantile Epilepsy: Acquired and Genetic Models.Cold Spring Harbor perspectives in medicine · 2015Review
- Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studies.Neurobiology of disease · 2015Review
- Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering.Pflugers Archiv : European journal of physiology · 2015Article
- Methionine increases BDNF DNA methylation and improves memory in epilepsy.Annals of clinical and translational neurology · 2015Article
- Antiepileptic drug treatment of rolandic epilepsy and Panayiotopoulos syndrome: clinical practice survey and clinical trial feasibility.Archives of disease in childhood · 2015Review
- What is more harmful, seizures or epileptic EEG abnormalities? Is there any clinical data?Epileptic disorders : international epilepsy journal with videotape · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Frequent interictal spikes are a common finding in the electroencephalograms of children with epileptic encephalopathies. While it is well recognized that interictal spikes are a biological marker of seizures and can lead to transitory cognitive impairment, whether interictal spikes can result in long-standing adverse effects on learning and memory in children is not known. Here we investigated the consequences of interictal spikes in rat pups without seizures on long-term learning and memory. Rat pups were given a low dose of flurothyl for 4h for 10 days during continuous electroencephalographic monitoring. Rats developed interictal spikes without seizures while age-matched controls under similar testing conditions had few interictal spikes. When rats were tested as adults, there was impairment in reference memory in the probe test of the Morris water maze, reference memory impairment in the four-trial radial-arm water maze and impaired long-term potentiation. Early-life interictal spikes resulted in impaired new cell formation and decreased cell counts in the hippocampus but did not cause an increase in apoptosis. This study, for the first time demonstrates that interictal spikes in rat pups without seizures can result in long-standing spatial cognitive impairment. Our findings suggest that suppressing IIS may be as important as treating seizures during brain development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.