ArticleNeurobiology of disease2010
In vitro ictogenesis and parahippocampal networks in a rodent model of temporal lobe epilepsy.
Article in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Interneuron-Driven Ictogenesis in the 4-Aminopyridine Model: Depolarization Block and Potassium Accumulation Initiate Seizure-like Activity.International journal of molecular sciences · 2025Article
- Article
- Lamotrigine Attenuates Neuronal Excitability, Depresses GABA Synaptic Inhibition, and Modulates Theta Rhythms in Rat Hippocampus.International journal of molecular sciences · 2021Article
- Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy.Acta neuropathologica · 2021Article
- Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of Epilepsy.International journal of molecular sciences · 2018Review
- Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays.Journal of visualized experiments : JoVE · 2018Article
- The Subiculum: A Potential Site of Ictogenesis in a Neonatal Seizure Model.Frontiers in neurology · 2017Article
- Neurosteroidal modulation of in vitro epileptiform activity is enhanced in pilocarpine-treated epileptic rats.Neurobiology of disease · 2015Article
- Limbic networks and epileptiform synchronization: the view from the experimental side.International review of neurobiology · 2014Review
- Perirhinal cortex and temporal lobe epilepsy.Frontiers in cellular neuroscience · 2013Review
- Does interictal synchronization influence ictogenesis?Neuropharmacology · 2013Review
- Adaptive control of epileptiform excitability in an in vitro model of limbic seizures.Experimental neurology · 2013Article
- Evidence-based modeling of network discharge dynamics during periodic pacing to control epileptiform activity.Journal of neuroscience methods · 2012Article
- Cell type-specific properties of subicular GABAergic currents shape hippocampal output firing mode.PloS one · 2012Article
- GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity.Progress in neurobiology · 2011Review
- High-frequency (80-500 Hz) oscillations and epileptogenesis in temporal lobe epilepsy.Neurobiology of disease · 2011Article
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6 authors.
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Abstract
Temporal lobe epilepsy (TLE) is a chronic epileptic disorder involving the hippocampal formation. Details on the interactions between the hippocampus proper and parahippocampal networks during ictogenesis remain, however, unclear. In addition, recent findings have shown that epileptic limbic networks maintained in vitro are paradoxically less responsive than non-epileptic control (NEC) tissue to application of the convulsant drug 4-aminopyridine (4AP). Field potential recordings allowed us to establish here the effects of 4AP in brain slices obtained from NEC and pilocarpine-treated epileptic rats; these slices included the hippocampus and parahippocampal areas such as entorhinal and perirhinal cortices and the amygdala. First, we found that both types of tissue generate epileptiform discharges with similar electrographic characteristics. Further investigation showed that generation of robust ictal-like discharges in the epileptic rat tissue is (i) favored by decreased hippocampal output (ii) reinforced by EC-subiculum interactions and (iii) predominantly driven by amygdala networks. We propose that a functional switch to alternative synaptic routes may promote network hyperexcitability in the epileptic limbic system.
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