ReviewClinical nutrition (Edinburgh, Scotland)2010
Hormone treatment and muscle anabolism during aging: androgens.
Review in Clinical nutrition (Edinburgh, Scotland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03678233 (Efficacy of Testosterone Gel to Restore Normal Serum Values of Testosterone During the Acute Phase of Critical Illness in Adult ICU Patients), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Testosterone Gel to Restore Normal Serum Values of Testosterone During the Acute Phase of Critical Illness in Adult ICU Patients
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Efficacy of Testosterone plus NASA Exercise Countermeasures during Head-Down Bed Rest.Medicine and science in sports and exercise · 2018Trial
- Translational studies in older men using testosterone to treat sarcopenia.Transactions of the American Clinical and Climatological Association · 2014Trial
- Sarcopenia: Current Insights into Molecular Mechanisms, Diagnostics, and Emerging Interventional Approaches.International journal of molecular sciences · 2025Review
- Skeletal muscle dysfunction with advancing age.Clinical science (London, England : 1979) · 2024Review
- Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model.Scientific reports · 2023Article
- Association of testosterone therapy with disease progression in older males with COVID-19.Andrology · 2022Article
- Combination of selective androgen and estrogen receptor modulators in orchiectomized rats.Journal of endocrinological investigation · 2022Article
- Computational Analysis of Residue-Specific Binding Free Energies of Androgen Receptor to Ligands.Frontiers in molecular biosciences · 2021Article
- Nutrition and microRNAs: Novel Insights to Fight Sarcopenia.Antioxidants (Basel, Switzerland) · 2020Review
- Sex Hormones and Novel Corona Virus Infectious Disease (COVID-19).Mayo Clinic proceedings · 2020Review
- Exercise and Testosterone Countermeasures to Mitigate Metabolic Changes during Bed Rest.Life sciences in space research · 2020Article
- Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays.Genomics, proteomics & bioinformatics · 2018Article
- The Beneficial Effects of Taurine to Counteract Sarcopenia.Current protein & peptide science · 2018Review
- Muscle changes in aging: understanding sarcopenia.Sports health · 2014Article
- Nutritionally essential amino acids and metabolic signaling in aging.Amino acids · 2013Review
- Supra-physiological doses of testosterone affect membrane oxidation of human neutrophils monitored by the fluorescent probe C₁₁-BODIPY⁵⁸¹/⁵⁹¹.European journal of applied physiology · 2013Article
- Androgen receptor polyglutamine repeat number: models of selection and disease susceptibility.Evolutionary applications · 2013Article
- The role of androgens and estrogens on healthy aging and longevity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Breakthrough in cachexia treatment through a novel selective androgen receptor modulator?!Journal of cachexia, sarcopenia and muscle · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Aging is associated with a gradual decline in circulating testosterone concentrations and decreased musculature in men. While testosterone administration is often considered when symptoms of hypogonadism are presented, the long-term effects of androgen use on muscle physiology are not yet fully understood. The definition of hypogonadism in men remains obscure but is generally indicated by total testosterone concentrations less than a threshold value of 300-500 ng/dL. Androgen replacement therapy is generally safe in men and women with low endogenous testosterone concentrations. The development of selective androgen receptor modulators (SARMs) may provide additional options in treatment of hypogonadism while lowering the potential of side effects often associated with long-term androgen use. Androgen administration, either alone or in combination with other treatments, can be successful in improving muscle mass by increasing protein anabolism and reducing protein catabolism in men and women. Further research is necessary to optimize the anabolic and anticatabolic properties of androgens for treatment and prevention of muscle loss in men and women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.