Evidence map›Paper›PMID 20451868›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2010

The Alzheimer's disease neuroimaging initiative: progress report and future plans.

Michael W Weiner, Paul S Aisen, Clifford R Jack, William J Jagust, John Q Trojanowski, Leslie Shaw, Andrew J Saykin, John C Morris, Nigel Cairns, Laurel A Beckett and 10 more

Registry-linked trialOpen access · bronzeAbstract readHistorical ArticleReview
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01687153 (Effects of Traumatic Brain Injury and Post Traumatic Stress Disorder on Alzheimer's Disease), which is not on this map. Cited by 321 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
321citing papers in PubMed, 5 pooled it
24.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01687153 completednot on this mapstarted 2012, after this paper: background citation

Effects of Traumatic Brain Injury and Post Traumatic Stress Disorder on Alzheimer's Disease (AD) in Veterans Using Alzheimer's Disease Neuroimaging Initiative (ADNI)

TypeobservationalSponsorUniversity of Southern CaliforniaRan2012 to 2021Enrolled289ConditionsTraumatic Brain Injury, Post Traumatic Stress Disorder, Alzheimer's Disease, Mild Cognitive Impairment
3 · Its place in the literature

Who cites it

321 citing papers in PubMed, 5 syntheses or guidelines pooled it, 596 citations in OpenAlex.

  1. Pooled it
  2. Interpretable machine learning for dementia: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. A Variational Mean-Field Control Framework for Graph Representation Learning.IEEE transactions on pattern analysis and machine intelligence · 2026
    Article
  7. The Next Frontier in Quantitative Co-Clinical Imaging to Advance Functional Precision Oncology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
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  15. Gene-Modulated Network Diffusion for Improved Modeling of Amyloid-bioRxiv : the preprint server for biology · 2026
    Article
  16. Article
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  18. RBFOX1 association with age at onset of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  19. Article
  20. Article

261 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 1 country.

Michael W WeinerCenter for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, CA, USA. michael.weiner@ucsf.edu
Paul S Aisen
Clifford R Jack
William J Jagust
John Q Trojanowski
Leslie Shaw
Andrew J Saykin
John C Morris
Nigel Cairns
Laurel A Beckett
Arthur Toga
Robert Green
Sarah Walter
Holly Soares
Peter Snyder
Eric Siemers
William Potter
Patricia E Cole
Mark Schmidt
Alzheimer's Disease Neuroimaging Initiative
University of California, San Diego · USUniversity of Pennsylvania · USWashington University in St. Louis · USBoston University · USBrown University · USEli Lilly (United States) · USIndiana University Bloomington · USMayo Clinic in Arizona · USMedpace (United States) · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USPfizer (United States) · USSan Francisco VA Medical Center · USUniversity of California, Berkeley · USUniversity of California, Davis · USUniversity of California, Los Angeles · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
RECRUITMENT COREU19AG010483 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDMAN, HOWARD · 2013 to 2020
$80.6M
NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG010483
6 · The paper itself

Abstract

The Alzheimer's Disease Neuroimaging Initiative (ADNI) beginning in October 2004, is a 6-year research project that studies changes of cognition, function, brain structure and function, and biomarkers in elderly controls, subjects with mild cognitive impairment, and subjects with Alzheimer's disease (AD). A major goal is to determine and validate MRI, PET images, and cerebrospinal fluid (CSF)/blood biomarkers as predictors and outcomes for use in clinical trials of AD treatments. Structural MRI, FDG PET, C-11 Pittsburgh compound B (PIB) PET, CSF measurements of amyloid beta (Abeta) and species of tau, with clinical/cognitive measurements were performed on elderly controls, subjects with mild cognitive impairment, and subjects with AD. Structural MRI shows high rates of brain atrophy, and has high statistical power for determining treatment effects. FDG PET, C-11 Pittsburgh compound B PET, and CSF measurements of Abeta and tau were significant predictors of cognitive decline and brain atrophy. All data are available at UCLA/LONI/ADNI, without embargo. ADNI-like projects started in Australia, Europe, Japan, and Korea. ADNI provides significant new information concerning the progression of AD.

Indexed as

Disease ProgressionAlzheimer DiseaseAmericasBrainBrain MappingDiagnostic ImagingHistory, 21st CenturyHumansInternational CooperationLongitudinal StudiesModels, BiologicalMulticenter Studies as TopicProgram DevelopmentRadionuclide Imaging

Identifiers

PMID20451868
PMCPMC2927112
OpenAlexW2001477615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.