Evidence map›Paper›PMID 20450439›Full record

ReviewOmics : a journal of integrative biology2010

Proteoglycomics: recent progress and future challenges.

Mellisa Ly, Tatiana N Laremore, Robert J Linhardt

Abstract readReview
In one paragraph

Review in Omics : a journal of integrative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Synthetic heparan sulfate standards and machine learning facilitate the development of solid-state nanopore analysis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Analysis of the Glycosaminoglycan Chains of Proteoglycans.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Cancer Cell Glycocalyx and Its Significance in Cancer Progression.International journal of molecular sciences · 2018
    Review
  14. Review
  15. Article
  16. Article
  17. Glycans and glycoproteins as specific biomarkers for cancer.Analytical and bioanalytical chemistry · 2017
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mellisa LyDepartment of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York, USA.
Tatiana N Laremore
Robert J Linhardt

Funding

In vitro synthesis of recombinant heparan sulfateR01HL094463 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIAN, PAWLINSKI, RAFAL L · 2009 to 2021
$5.2M
Synthetic Heparan Sulfate: Probing Biosynthesis to Prepare Defined DrugsR01HL062244 · NHLBI · UNIVERSITY OF IOWA · PI DEANGELIS, PAUL L, LINHARDT, ROBERT J · 2001 to 2016
$4.1M
SEQUENCING THE POLYSACCHARIDE COMPONENT OF PROTEOGLYCANSR01GM038060 · NIGMS · UNIVERSITY OF IOWA · PI LINHARDT, ROBERT J · 1988 to 2012
$2.8M
An Artificial Golgi: Controlled GAG Synthesis and ScreeningR01GM090257 · NIGMS · RENSSELAER POLYTECHNIC INSTITUTE · PI DORDICK, JONATHAN S., LINHARDT, ROBERT J · 2009 to 2010
$597k
Heparin Glycan Microarray for ScreeningR41RR023764 · NCRR · SOLIDUS BIOSCIENCES, INC. · PI LINHARDT, ROBERT J · 2007 to 2008
$400k
NCRR NIH HHS RR023764NHLBI NIH HHS HL094463NHLBI NIH HHS HL62244NIGMS NIH HHS GM090257NIGMS NIH HHS GM38060
6 · The paper itself

Abstract

Proteoglycomics is a systematic study of structure, expression, and function of proteoglycans, a posttranslationally modified subset of a proteome. Although relying on the established technologies of proteomics and glycomics, proteoglycomics research requires unique approaches for elucidating structure-function relationships of both proteoglycan components, glycosaminoglycan chain, and core protein. This review discusses our current understanding of structure and function of proteoglycans, major players in the development, normal physiology, and disease. A brief outline of the proteoglycomic sample preparation and analysis is provided along with examples of several recent proteoglycomic studies. Unique challenges in the characterization of glycosaminoglycan component of proteoglycans are discussed, with emphasis on the many analytical tools used and the types of information they provide.

Indexed as

GlycomicsGlycosaminoglycansProteinsProteomicsAnimalsCarbohydrate ConformationCarbohydrate SequenceMolecular Sequence DataMolecular StructureProtein ConformationGlycosaminoglycansProteins

Identifiers

PMID20450439
PMCPMC3133783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.